Published online Jul 14, 2013. doi: 10.3748/wjg.v19.i26.4252
Revised: May 4, 2013
Accepted: May 16, 2013
Published online: July 14, 2013
Core tip: Lymphocytic colitis (LC), together with collagenous colitis (CC) is a part of the spectrum of “microscopic colitis” (MC) characterized by profuse non-bloody watery diarrhea, without endoscopic or radiological lesions, but with histological abnormalities. The association between LC and inflammatory bowel disease (IBD) is weak and unclear. The case reports of CC progressing to ulcerative colitis (UC) and vice versa has been previously reported but however to our knowledge we report the first case series of six patients with chronic UC subsequently developing into CC or LC suggesting MC could be a part of the spectrum of IBD.