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World J Gastroenterol. Jul 7, 2013; 19(25): 3980-3989
Published online Jul 7, 2013. doi: 10.3748/wjg.v19.i25.3980
Published online Jul 7, 2013. doi: 10.3748/wjg.v19.i25.3980
Polydatin attenuated food allergy via store-operated calcium channels in mast cell
Bo Yang, Jian-Jie Li, Cheng-Bin Yang, Qiong-Mei Ji, Zhi-Gang Liu, Allergy Branch of the State Key Laboratory of Respiratory Disease, School of Medicine, Shenzhen University, Shenzhen 518060, Guangdong Province, China
Ji-Juan Cao, Liaoning Entry-Exit Inspection and Quarantine Bureau, Dalian 116001, Liaoning Province, China
Jie Liu, Department of Pathophysiology, School of Medicine, Shenzhen University, Shenzhen 518060, Guangdong Province, China
Author contributions: Yang B, Li JJ, Liu J, Ji QM and Liu ZG designed the research; Yang B, Li JJ, Cao JJ and Yang CB performed the experiments; Yang B and Li JJ analyzed the data and wrote the manuscript; Yang B, Liu J and Liu ZG edited the manuscript; Yang B and Li JJ contributed equally to this work.
Supported by The Natural Science Foundation of China, No. 81271950, to Ji QM; Projects of International/HMT (Hong Kong, Macau, and Taiwan) Cooperation and Innovation Platform in Science and Technology of Guangdong Higher Education Institutions, No. 2012gjhz0009, to Liu ZG; Key Laboratory Construction Program of Shenzhen, No. SW201110010, to Liu ZG; and Basic Research Program of Shenzhen University, No. 201101, to Liu ZG; Basic Research Foundation of Shenzhen, No. JC201005250059A, JCYJ20120613115535998
Correspondence to: Zhi-Gang Liu, Professor, MD, PhD, Allergy Branch of the State Key Laboratory of Respiratory Disease, School of Medicine, Shenzhen University, Rm722, Composite Building, Nan Hai Ave 3688, Shenzhen 518060, Guangdong Province, China. lzg@szu.edu.cn
Telephone: +86-755-86671907 Fax: +86-755-86671906
Received: February 22, 2013
Revised: April 10, 2013
Accepted: May 16, 2013
Published online: July 7, 2013
Revised: April 10, 2013
Accepted: May 16, 2013
Published online: July 7, 2013
Core Tip
Core tip: In the present study, we have demonstrated for the first time that polydatin has the capacity for preventing pathogenesis of food allergy, which is dependent on regulation of Ca2+ mobilization via store-operated calcium channels in mast cells.