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World J Gastroenterol. Jun 28, 2013; 19(24): 3847-3853
Published online Jun 28, 2013. doi: 10.3748/wjg.v19.i24.3847
Published online Jun 28, 2013. doi: 10.3748/wjg.v19.i24.3847
Mitochondrial ATP 6 and 8 polymorphisms in irritable bowel syndrome with diarrhea
Wei-Feng Wang, Ming-Zhou Guo, Yun-Sheng Yang, Li-Hua Peng, Yong-Hua Wang, Hui-Hui Li, Department of Gastroenterology and Hepatology, Chinese PLA General Hospital, Beijing 100853, China
Xin Li, Department of Internal Medicine, Chinese PLA General Hospital, Beijing 100853, China
Jian-De Chen, Division of Gastroenterology and Hepatology, Department of Internal Medicine, University of Texas Medical Branch, Galveston, TX 77555-0764, United States
Chun-Yan Zhang, Department of Gastroenterology, Chinese Navy General Hospital, Beijing 10030, China
Author contributions: Wang WF and Li X contributed equally to this work; Wang WF and Li X conceived the study, performed experiments, collected data and drafted the manuscript; Guo MZ, Chen JD, Peng LH and Zhang CY participated in designing the study, interpreted results of experiments; Yang YS designed the study and critically reviewed the paper; Wang YH and Li HH performed experiments.
Correspondence to: Yun-Sheng Yang, MD, Director, Department of Gastroenterology and Hepatology, Chinese PLA General Hospital, 28 Fuxing Road, Beijing 100853, China. sunny888@medmail.com.cn
Telephone: +86-10-68154653 Fax: +86-10-68154653
Received: February 6, 2013
Revised: March 30, 2013
Accepted: April 9, 2013
Published online: June 28, 2013
Revised: March 30, 2013
Accepted: April 9, 2013
Published online: June 28, 2013
Core Tip
Core tip: Mitochondrial DNA, the only source of extranuclear genome, was assessed by Camilleri’s group in a study of patients with functional gastrointestinal disorders in 2009 which was the first study exploring the possible role of mitochondrial DNA in irritable bowel syndrome (IBS). Up till now, few research efforts have focused on this topic and there is little knowledge about it. Present study revealed that mitochondrial ATP 6 and 8 genes were more frequently mutated in IBS with diarrhea than in healthy individuals. We believe this preliminary finding could help promote future research on mitochondrial DNA in IBS.