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World J Gastroenterol. Jun 28, 2013; 19(24): 3781-3791
Published online Jun 28, 2013. doi: 10.3748/wjg.v19.i24.3781
Published online Jun 28, 2013. doi: 10.3748/wjg.v19.i24.3781
Glycyrrhizic acid attenuates CCl4-induced hepatocyte apoptosis in rats via a p53-mediated pathway
Xiao-Ling Guo, Bo Liang, Xue-Wei Wang, Fu-Gang Fan, Jing-Hui Yang, Xiao-Chun Wang, Lei Jin, Qin Cao, Department of Gastroenterology, Putuo Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai 200062, China
Jing Jin, Rui Lan, Zhongshan Hospital, Fudan University, Shanghai 200032, China
Author contributions: Guo XL and Liang B contributed equally to this work; Guo XL and Liang B performed the majority of experiments and wrote the manuscript; Wang XW, Wang XC and Jin L provided vital reagents; Fan FG and Yang JH offered vital analytical tools; Jin J and Lan R were involved in revising the manuscript; Cao Q designed the study and provided financial support for this work.
Supported by Leading Academic Discipline Project of State Administration of Traditional Chinese Medicine of China
Correspondence to: Dr. Qin Cao, Department of Gastroenterology, Putuo Hospital, Shanghai University of Traditional Chinese Medicine, No. 164 Lanxi Road, Shanghai 200062, China. caoqin434@sina.com
Telephone: +86-21-62572723 Fax: +86-21-52665957
Received: February 24, 2013
Revised: May 14, 2013
Accepted: May 18, 2013
Published online: June 28, 2013
Revised: May 14, 2013
Accepted: May 18, 2013
Published online: June 28, 2013
Core Tip
Core tip: This study is the first to investigate the effects of glycyrrhizic acid (GA) on p53-dependent apoptosis in carbon tetrachloride (CCl4)-induced hepatic injury. The results indicated that GA can attenuate hepatocyte apoptosis via a p53-mediated mitochondrial pathway and retard the progression of liver fibrosis induced by CCl4 in rats.