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World J Gastroenterol. Jun 21, 2013; 19(23): 3658-3664
Published online Jun 21, 2013. doi: 10.3748/wjg.v19.i23.3658
Published online Jun 21, 2013. doi: 10.3748/wjg.v19.i23.3658
Analysis of long non-coding RNA expression profiles in gastric cancer
Wei-Jun Cao, Hai-Lu Wu, Yu-Shu Zhang, Zhen-Yu Zhang, Department of Gastroenterology, Nanjing First Hospital, Nanjing Medical University, Nanjing 210006, Jiangsu Province, China
Bang-Shun He, Central Laboratory, Nanjing First Hospital, Nanjing Medical University, Nanjing 210006, Jiangsu Province, China
Author contributions: Cao WJ designed the study; Cao WJ, Wu HL, He BS and Zhang YS performed the data analysis; Cao WJ and Wu HL wrote the manuscript; Zhang ZY revised and approved the manuscript.
Correspondence to: Dr. Zhen-Yu Zhang, Department of Gastroenterology, Nanjing First Hospital, Nanjing Medical University, 68 Changle Road, Nanjing 210006, Jiangsu Province, China. zhangzhenyu808@126.com
Telephone: +86-25-87726249 Fax: +86-25-87726249
Received: January 22, 2013
Revised: March 20, 2013
Accepted: May 9, 2013
Published online: June 21, 2013
Revised: March 20, 2013
Accepted: May 9, 2013
Published online: June 21, 2013
Core Tip
Core tip: Long non-coding RNAs (lncRNAs) have risen to prominence with important roles in a broad range of biological processes. LncRNA expression patterns and their biological functions in gastric cancer still remain unknown. We re-annotated the probes from an Affymetrix Human Exon 1.0 ST array and identified probes uniquely mapping to lncRNAs at the gene level. These probes correspond to 9294 lncRNAs, covering nearly 76% of the GENCODE lncRNA data set. We identified a set of lncRNAs that were differentially expressed in gastric cancer. In an independent data set, 59% of these differentially expressed lncRNAs showed significant expression changes with the same direction.