Original Article
Copyright ©2013 Baishideng Publishing Group Co., Limited. All rights reserved.
World J Gastroenterol. Jun 14, 2013; 19(22): 3415-3422
Published online Jun 14, 2013. doi: 10.3748/wjg.v19.i22.3415
Disruption of interstitial cells of Cajal networks after massive small bowel resection
Jie Chen, Lei Du, Yong-Tao Xiao, Wei Cai
Jie Chen, Lei Du, Wei Cai, Department of Pediatric Surgery, Xin Hua Hospital, Shanghai Jiaotong University School of Medicine, Shanghai 200092, China
Jie Chen, Department of Pediatric Surgery, School of Medicine, Affiliated Hospital of Nantong University, Nantong 226001, Jiangsu Province, China
Yong-Tao Xiao, Wei Cai, Shanghai Key Laboratory of Pediatric Gastroenterology and Nutrition, Shanghai Institute of Pediatric Research, Shanghai Jiaotong University, Shanghai 200092, China
Author contributions: Chen J and Cai W designed the research; Chen J and Du L performed the research; Xiao YT analyzed the data; Chen J wrote the paper.
Supported by Grants from the Program for Innovative Research Team of Shanghai Municipal Education Commission and Special Foundation of Shanghai Municipal Public Health Bureau, LJ06021; the National Natural Science Foundation of China, No. 30772270, 30972427; and the Scientific Foundation of Nantong University, No. 10Z046
Correspondence to: Wei Cai, MD, PhD, Department of Pediatric Surgery, Xin Hua Hospital, Shanghai Jiaotong University School of Medicine, 1665 Kong Jiang Road, Shanghai 200092, China. caiw204@yahoo.com.cn
Telephone: + 86-21-65790000 Fax: +86-21-65011627
Received: December 15, 2012
Revised: February 22, 2013
Accepted: April 13, 2013
Published online: June 14, 2013
Core Tip

Core tip: Several gastrointestinal motility diseases are associated with altered numbers of interstitial cells of Cajal (ICC). Short bowel syndrome is also characterized by disordered intestinal motility immediately after surgery. We have investigated the alterations in numbers and functional changes of ICC that occur as a result of short bowel syndrome. In summary, our study showed modifications of the ultrastructure morphology of ICC, altered numbers of ICC and subsequent altered electrophysiological functional activity in the ileum after massive small bowel resection. However, the association between motility disorders and the changes of ICC should be further evaluated.