Published online Jun 14, 2013. doi: 10.3748/wjg.v19.i22.3415
Revised: February 22, 2013
Accepted: April 13, 2013
Published online: June 14, 2013
Core tip: Several gastrointestinal motility diseases are associated with altered numbers of interstitial cells of Cajal (ICC). Short bowel syndrome is also characterized by disordered intestinal motility immediately after surgery. We have investigated the alterations in numbers and functional changes of ICC that occur as a result of short bowel syndrome. In summary, our study showed modifications of the ultrastructure morphology of ICC, altered numbers of ICC and subsequent altered electrophysiological functional activity in the ileum after massive small bowel resection. However, the association between motility disorders and the changes of ICC should be further evaluated.