Brief Article
Copyright ©2013 Baishideng Publishing Group Co., Limited. All rights reserved.
World J Gastroenterol. Jun 7, 2013; 19(21): 3272-3280
Published online Jun 7, 2013. doi: 10.3748/wjg.v19.i21.3272
Low trypsinogen-1 expression in pediatric ulcerative colitis patients who undergo surgery
Maija Piekkala, Jaana Hagström, Maarit Tanskanen, Risto Rintala, Caj Haglund, Kaija-Leena Kolho
Maija Piekkala, Risto Rintala, Kaija-Leena Kolho, Children’s Hospital, University of Helsinki, FIN-00029 HUS, Helsinki, Finland
Jaana Hagström, Maarit Tanskanen, Department of Pathology, Haartman Institute, University of Helsinki, FIN-00029 HUS, Helsinki, Finland
Caj Haglund, Department of Surgery, Helsinki University Central Hospital, FIN-00029 HUS Helsinki, Finland
Author contributions: Kolho KL, Haglund C and Piekkala M designed the study; Rintala R mainly obtained the biopsies; Hagström J, Piekkala M and Tanskanen M performed the histological analysis of the samples; Piekkala M analyzed the data; Piekkala M wrote the first draft of the manuscript; all authors took part in the critical revision of the paper.
Supported by Päivikki and Sakari Sohlberg Foundation, to Piekkala M; Helsinki University Central Hospital Grant, to Kolho KL; and the Finnish Pediatric Research Foundation, to Kolho KL
Correspondence to: Maija Piekkala, BMed, Children’s Hospital, University of Helsinki, PO Box 281, FIN-00029 HUS, Helsinki, Finland. maija.piekkala@helsinki.fi
Telephone: +358-40-7615172 Fax: +358-9-47186478
Received: November 20, 2012
Revised: April 15, 2013
Accepted: April 18, 2013
Published online: June 7, 2013
Processing time: 195 Days and 17.6 Hours
Core Tip

Core tip: The risk factors for aggressive pediatric ulcerative colitis (UC) were studied in 24 patients who had undergone surgery by staining diagnostic tissue samples for matrix metalloproteinase-9 and trypsinogen-1 (Tryp-1) and Tryp-2, as well as a trypsin inhibitor. In the UC group, there were significantly more samples that were matrix metalloproteinase-9 positive in comparison to the samples from non-inflammatory bowel disease patients. UC patients undergoing colectomy showed lower immunopositivity of Tryp-1 in the colon epithelium in their diagnostic biopsies when compared to that of conservatively treated patients and non-inflammatory bowel disease patients. The discovery of a low trypsinogen level at diagnosis warrants further study.