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World J Gastroenterol. May 28, 2013; 19(20): 3130-3133
Published online May 28, 2013. doi: 10.3748/wjg.v19.i20.3130
Published online May 28, 2013. doi: 10.3748/wjg.v19.i20.3130
Expression of huCdc7 in colorectal cancer
Hai-Jun Chen, Zhen Zhu, Xue-Lin Wang, Quan-Lin Feng, Qing Wu, Zheng-Ping Xu, Jiang Wu, Xiao-Feng Yu, Hong-Liang Qian, Qi Lu, Department of Oncology, Kunshan Hospital of Traditional Chinese Medicine Affiliated to Nanjing University of Chinese Medicine, Kunshan 215300, Jiangsu Province, China
Author contributions: Chen HJ, Zhu Z and Lu Q designed the research; Wang XL, Feng QL, Wu Q, Xu ZP and Wu J performed research; Chen HJ, Yu XF, Qian HL and Lu Q analyzed the data; all the authors contributed to the preparation of the manuscript.
Correspondence to: Dr. Hai-Jun Chen, Department of Oncology, Kunshan Hospital of Traditional Chinese Medicine Affiliated to Nanjing University of Chinese Medicine, No. 189 Chaoyang Road, Kunshan 215300, Jiangsu Province, China. ksschj@126.com
Telephone: +86-512-57310000 Fax: +86-512-57928140
Received: March 7, 2013
Revised: March 29, 2013
Accepted: April 3, 2013
Published online: May 28, 2013
Revised: March 29, 2013
Accepted: April 3, 2013
Published online: May 28, 2013
Core Tip
Core tip: huCdc7 is ubiquitously expressed in human tissues and can regulate DNA replication initiation. Abnormal expression or excessive activation of huCdc7 can promote excessive cell proliferation and cause tumorigenesis. Colorectal cancer is a common digestive tract tumor with a gradually increasing incidence. We found that huCdc7 may play an important role in the development and progression of colorectal cancer.