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World J Gastroenterol. May 21, 2013; 19(19): 2921-2934
Published online May 21, 2013. doi: 10.3748/wjg.v19.i19.2921
Published online May 21, 2013. doi: 10.3748/wjg.v19.i19.2921
Inhibiting heme oxygenase-1 attenuates rat liver fibrosis by removing iron accumulation
Qiu-Ming Wang, Zhi-Jun Duan, Shi-Bin Guo, Xiao-Yu Sun, Zhen Liu, Department of Gastroenterology, First Affiliated Hospital of Dalian Medical University, Dalian 116011, Liaoning Province, China
Jian-Ling Du, Department of Endocrinology, First Affiliated Hospital of Dalian Medical University, Dalian 116011, Liaoning Province, China
Author contributions: Wang QM and Du JL performed the experiments, analyzed the data and wrote the manuscript; Duan ZJ and Wang QM designed the experiments; Wang QM performed the experiments, analyzed the data and wrote the manuscript; Duan ZJ and Guo SB revised the manuscript.
Supported by Grants from the National Natural Science Foundation of China, No. 30970886; The Science and Technology Project of Dalian, No. 2010E15SF179; and the Initial Doctoral funding of Liaoning Province, No. 20121110
Correspondence to: Zhi-Jun Duan, Professor, Department of Gastroenterology, First Affiliated Hospital of Dalian Medical University, No. 222 Zhongshan Road, Dalian 116011, Liaoning Province, China. cathydoctor@sina.com
Telephone: +86-411-83635963 Fax: +86-411-83632383
Received: January 13, 2013
Revised: March 15, 2013
Accepted: March 28, 2013
Published online: May 21, 2013
Revised: March 15, 2013
Accepted: March 28, 2013
Published online: May 21, 2013
Core Tip
Core tip: In this study, inhibiting heme oxygenase-1 (HO-1)/carbon monoxide (CO) system by zinc protoporphyrin in rat liver fibrosis induced by bile duct ligation, the author aimed to affect the HO-1/CO system by iron deposition and portal pressure. Reducing hepatic iron deposition and CO levels by inhibiting HO-1 activity though the nuclear factor-E2-related factor 2/Keap pathway could be helpful in improving hepatic fibrosis and maintaining portal vein pressure.