Mycotoxins are conventional and novel risk biomarkers for hepatocellular carcinoma

doi:10.3748/wjg.v19.i17.2587

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May 7, 2013 (publication date) through Apr 25, 2024

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World Journal of Gastroenterology

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1007-9327

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World J Gastroenterol. May 7, 2013; 19(17): 2587-2590
Published online May 7, 2013. doi: 10.3748/wjg.v19.i17.2587

Mycotoxins are conventional and novel risk biomarkers for hepatocellular carcinoma

Yasunobu Matsuda, Toshifumi Wakai, Masayuki Kubota, Mami Osawa, Ayumi Sanpei, Shun Fujimaki

Yasunobu Matsuda, Ayumi Sanpei, Shun Fujimaki, Department of Medical Technology, Niigata University Graduate School of Health Sciences, Niigata 951-8518, Japan

Toshifumi Wakai, Division of Digestive and General Surgery, Niigata University Graduate School of Medical and Dental Sciences, Niigata 951-8510, Japan

Masayuki Kubota, Mami Osawa, Division of Pediatric Surgery, Niigata University Graduate School of Medical and Dental Sciences, Niigata 951-8510, Japan

Author contributions: Matsuda Y collected the materials and wrote the manuscript; Wakai T discussed the topic; Kubota M supervised the publication of this commentary; Osawa M, Sanpei A, and Fujimaki S collected the materials.

Correspondence to: Yasunobu Matsuda, MD, Department of Medical Technology, Niigata University Graduate School of Health Sciences, 2-746 Asahimachi-dori, Niigata 951-8518, Japan. yasunobu@med.niigata-u.ac.jp

Telephone: +81-25-2272357 Fax: +81-25-2270749

Received: January 23, 2013
Revised: March 10, 2013
Accepted: March 21, 2013
Published online: May 7, 2013

Core Tip

Core tip: Mycotoxins are one of the possible important carcinogens of hepatocellular carcinoma (HCC). Recently, a chromatographic separation technique based on high-performance liquid chromatography (HPLC) has been recognized as a useful method for the quantitative analyses of mycotoxins in the sera of individuals. Using this technique, the serum levels of ochratoxin A, a type of food mycotoxin widely spread in cereals, has been recently reported to be increased in the sera of HCC patients in Egypt. HPLC-based analysis of mycotoxins in the clinical samples would provide some new epidemiological information about non-viral HCC.