Brief Article
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World J Gastroenterol. Apr 21, 2013; 19(15): 2419-2424
Published online Apr 21, 2013. doi: 10.3748/wjg.v19.i15.2419
Exposure to gastric juice may not cause adenocarcinogenesis of the esophagus
Peng Cheng, Jian-Sheng Li, Lian-Feng Zhang, Yong-Zhong Chen, Jun Gong
Peng Cheng, Jian-Sheng Li, Lian-Feng Zhang, Yong-Zhong Chen, Department of Gastroenterology, the First Hospital of Zhengzhou University, Zhengzhou 450052, Henan Province, China
Jun Gong, Department of Gastroenterology, the Second Hospital of Xi’an Jiao Tong University, Xi’an 710004, Shaanxi Province, China
Author contributions: Cheng P designed the study, wrote the manuscript and performed the majority of experiments; Li JS, Zhang LF and Chen YZ provided vital reagents and analytical tools and were also involved in revising the manuscript; Gong J designed the study and provided financial support for this work.
Correspondence to: Peng Cheng, MD, Associate Professor, Department of Gastroenterology, the First Hospital of Zhengzhou University, No. 1, Jianshe Donglu, Zhengzhou 450052, Henan Province, China. cpzxczzc2004@yahoo.com.cn
Telephone: +86-371-66862062 Fax: +86-371-66964992
Received: October 24, 2012
Revised: March 15, 2013
Accepted: March 21, 2013
Published online: April 21, 2013
Core Tip

Core tip: The incidence of esophageal adenocarcinoma (EAC) has rapidly increased, which may be related to the increased incidence of gastroesophageal reflux disease. A better understanding of how refluxate contributes to development of EAC will help decrease the incidence of cancer. We surgically developed a rat model of duodenogastroesophageal reflux and found that although exposure of the forestomach to gastric juice may induce inflammation and mild metaplasia, it does not lead to the development of metaplasia with dysplasia or adenocarcinoma. It is concluded that gastric juice may not be related to the development of EAC.