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World J Gastroenterol. Apr 21, 2013; 19(15): 2395-2403
Published online Apr 21, 2013. doi: 10.3748/wjg.v19.i15.2395
Published online Apr 21, 2013. doi: 10.3748/wjg.v19.i15.2395
Increased international normalized ratio level in hepatocellular carcinoma patients with diabetes mellitus
Hui Zhang, Chun Gao, Long Fang, Shu-Kun Yao, Department of Gastroenterology, China-Japan Friendship Hospital, Ministry of Health, Beijing 100029, China
Author contributions: Zhang H participated in the acquisition of data, statistical analysis and manuscript writing; Gao C and Fang L conceived the study, participated in the study design, acquisition of data, statistical analysis and manuscript writing; Yao SK participated in the study design and critical revision of manuscript for important intellectual content; all authors have read and approved the final manuscript.
Supported by National Natural Science Foundation of China, No. 81273975; and the Research Fund of the China-Japan Friendship Hospital, Ministry of Health, No. 2010-QN-01
Correspondence to: Long Fang, MD, Department of Gastroenterology, China-Japan Friendship Hospital, Ministry of Health, No. 2 Yinghua East Road, Beijing 100029, China. longfang76@sohu.com
Telephone: +86-10-84205313 Fax: +86-10-84205313
Received: December 24, 2012
Revised: January 11, 2013
Accepted: February 8, 2013
Published online: April 21, 2013
Revised: January 11, 2013
Accepted: February 8, 2013
Published online: April 21, 2013
Core Tip
Core tip: This study showed that the international normalized ratio (INR) level was an independent variable associated with diabetes mellitus (DM) in hepatocellular carcinoma (HCC) patients compared with those HCC patients without DM, after controlling for the confounding effect of age, systolic blood pressure, hemoglobin, platelet and hepatitis B virus infection by logistic analyses. Considering the effect of liver cirrhosis on results, a sub-group analysis was performed and the study population was restricted to those HCC patients with cirrhosis. A similar result was obtained. These results indicated that INR level was increased in HCC patients with DM and this is independent of liver cirrhosis.