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World J Gastroenterol. Apr 21, 2013; 19(15): 2319-2330
Published online Apr 21, 2013. doi: 10.3748/wjg.v19.i15.2319
Published online Apr 21, 2013. doi: 10.3748/wjg.v19.i15.2319
Effect of biliary drainage on inducible nitric oxide synthase, CD14 and TGR5 expression in obstructive jaundice rats
Zi-Kai Wang, Wen Li, Department of Gastroenterology and Hepatology, the General Hospital of the Chinese People’s Liberation Army, Beijing 100853, China
Jian-Guo Xiao, Critical Care Medicine, the General Hospital of the Chinese People’s Liberation Army, Beijing 100853, China
Xue-Fei Huang, Department of Cadre Health Care, the Navy General Hospital of the Chinese People’s Liberation Army, Beijing 100048, China
Yi-Chun Gong, Intensive Care Unit, the 309th Hospital of the Chinese People’s Liberation Army, Beijing 100091, China
Author contributions: Li W designed the research; Wang ZK, Xiao JG, Huang XF and Gong YC performed the majority of experiments and contributed equally to this work; Wang ZK and Li W wrote the paper.
Supported by National Natural Science Foundation of China, No. 30470790 and 30971355
Correspondence to: Wen Li, MD, PhD, Department of Gastroenterology and Hepatology, the General Hospital of the Chinese People’s Liberation Army, No. 28, Fuxing Road, Beijing 100853, China. liwencn2000@126.com
Telephone: +86-10-55499107 Fax: +86-10-88626386
Received: June 28, 2012
Revised: December 19, 2012
Accepted: March 6, 2013
Published online: April 21, 2013
Revised: December 19, 2012
Accepted: March 6, 2013
Published online: April 21, 2013
Core Tip
Core tip: To date, there are still controversies over whether and how to perform preoperative biliary drainage in patients with malignant or benign obstructive jaundice (OJ), even though the complication-related mortality rate for OJ patients was high after surgery. Internal biliary drainage could reverse the raised expression of inducible nitric oxide synthase and CD14 both in protein and messenger RNA levels in obstructive jaundice rat models, but external drainage could not. The mechanism of internal biliary drainage superior to external drainage in relief of obstructive jaundice might be attributed to the regulatory function of activation of Kupffer cells and release of inflammatory mediators.