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World J Gastroenterol. Apr 14, 2013; 19(14): 2249-2255
Published online Apr 14, 2013. doi: 10.3748/wjg.v19.i14.2249
Published online Apr 14, 2013. doi: 10.3748/wjg.v19.i14.2249
Effects of Lizhong Tang on cultured mouse small intestine interstitial cells of Cajal
Min Woo Hwang, Department of Sasang Constitutional Medicine, College of Korean Medicine, Kyung-hee University, Seoul 130-701, South Korea
Jung Nam Kim, Ho Jun Song, Bora Lim, Young Kyu Kwon, Byung Joo Kim, School of Korean Medicine, Pusan National University, Yangsan 626-870, South Korea
Author contributions: Kwon YK and Kim BJ designed the research; Hwang MW, Kim JN and Song HJ performed the experiments; Lim B, Kwon YK and Kim BJ analyzed the data; and Hwang MW and Kim BJ wrote the paper.
Supported by The Traditonal Korean Medicine R and D Project, Ministry of Health and Welfare, South Korea, No. B120008
Correspondence to: Byung Joo Kim, PhD, School of Korean Medicine, Pusan National University, Beomeori, Mulgeum-eup, Yangsan 626-870, South Korea. vision@pusan.ac.kr
Telephone: +82-51-5108469 Fax: +82-51-5108420
Received: November 12, 2012
Revised: February 6, 2013
Accepted: February 8, 2013
Published online: April 14, 2013
Revised: February 6, 2013
Accepted: February 8, 2013
Published online: April 14, 2013
Core Tip
Core tip: The gastroprokinetic effects of Lizhong Tang are mediated by the induction of pacemaker potentials in interstitial cells of Cajal (ICCs). Taken together, our data suggest that the gastroprokinetic effects of Lizhong Tang are mediated by the induction of pacemaker potentials in ICCs. Considering the effects of this drug on ICCs, further research is required to identify the compounds responsible for the effects of Lizhong Tang and to determine their mechanisms of action.