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World J Gastroenterol. Nov 21, 2010; 16(43): 5424-5434
Published online Nov 21, 2010. doi: 10.3748/wjg.v16.i43.5424
Published online Nov 21, 2010. doi: 10.3748/wjg.v16.i43.5424
Endogenous leptin fluctuates in hepatic ischemia/reperfusion injury and represents a potential therapeutic target
Ji Lin, Guang-Tao Yan, Hui Xue, Xiu-Hua Hao, Lu-Huan Wang, Research Laboratory of Biochemistry, Basic Medical Institute, Chinese PLA General Hospital, 28 Fuxing Road, Beijing 100853, China
Xiao-Ning Gao, Department of Hematology, Clinical Division of Internal Medicine, Chinese PLA General Hospital, 28 Fuxing Road, Beijing 100853, China
Author contributions: Lin J and Gao XN contributed equally to this work; Lin J and Yan GT designed the research; Xue H and Hao XH prepared leptin antibody and iodinated leptin; Lin J and Wang LH measured the serum variables; Lin J and Gao XN performed the histological evaluation and immunohistochemistry; Lin J, Gao XN and Yan GT analyzed the data and wrote the manuscript.
Supported by National Natural Science Foundation of China, No. 30670821; National Key Technology R&D Program, No. 2006BAF07B01; Special Funds for Key Program of Public Welfare of National Ministry of Science and Technology, No. 2002D1A40019; and Nursery Fund of Chinese PLA General Hospital, No. 06MP83
Correspondence to: Guang-Tao Yan, Professor, Research Laboratory of Biochemistry, Basic Medical Institute, Chinese PLA General Hospital, 28 Fuxing Road, Beijing 100853, China. yan301@263.net
Telephone: +86-10-66937072 Fax: +86-10-68176512
Received: August 10, 2010
Revised: September 13, 2010
Accepted: September 20, 2010
Published online: November 21, 2010
Revised: September 13, 2010
Accepted: September 20, 2010
Published online: November 21, 2010
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