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©2009 The WJG Press and Baishideng. All rights reserved.
World J Gastroenterol. Dec 7, 2009; 15(45): 5674-5684
Published online Dec 7, 2009. doi: 10.3748/wjg.15.5674
Published online Dec 7, 2009. doi: 10.3748/wjg.15.5674
Nicotinamide overload may play a role in the development of type 2 diabetes
Shi-Sheng Zhou, Da Li, Wu-Ping Sun, Yong-Zhi Lun, Fu-Cheng Xiao, Li-Xin Jing, Shen-Xia Sun, Ning Luo, Fu-Ning Bian, Sheng-Fan Li, Xiao-Jie Gong, Zeng-Guo Yu, Chang-Bin Sun, Cong-Long Zheng, Institute of Basic Medical Sciences, Medical College, Dalian University, Dalian 116622, Liaoning Province, China
Ming Guo, Zheng-Ning Li, College of Environmental and Chemical Engineering, Dalian University, Dalian 116622, Liaoning Province, China
Yi-Ming Zhou, Okazaki Institute for Integrative Bioscience, National Institutes of Natural Sciences, Okazaki 444-8787, Japan
Li-Bin Zhang, Department of Physiology, Xinxiang Medical College, Xinxiang 453003, Henan Province, China
Wei Zou, Department of Life Sciences, Liaoning Normal University, Dalian 116029, Liaoning Province, China
Lai-Bin Dong, Department of Neurology, PLA No. 91 Hospital, Jiaozuo 454003, Henan Province, China
Zhi-Gang Zhao, Dong-Ju Jiang, Department of Medicine, PLA No. 210 Hospital, Dalian 116021, Liaoning Province, China
Author contributions: Zhou SS was responsible for the study concept, design, direction and supervision, drafted the manuscript, and obtained funding; Li D, Sun WP, Lun YZ, Zhou YM, Xiao FC, Jing LX, Sun SX, Zhang LB, Luo N, Bian FN, Zou W, Gong XJ, Yu ZG, Sun CB and Zheng CL contributed to the program initiation, data acquisition and analysis/discussion, as well as writing and editing the manuscript; Guo M directed the HPLC separation and analysis; Dong LB, Zhao ZG, Li SF and Jiang DJ acquired the clinical cases and patient consent, and assisted in data collection; Li ZN synthesized the compounds.
Supported by National Natural Science Foundation of China, No. 30570665; the Foundation of Dalian Technology Bureau, No. 2008E13SF182; and the Foundation of Key Laboratory of Education Department of Liaoning Province, No. 2009S005
Correspondence to: Shi-Sheng Zhou, Professor, PhD, MD, Institute of Basic Medical Sciences, Medical College, Dalian University, Dalian 116622, Liaoning Province, China. zhouss@ymail.com
Telephone: +86-411-87402740 Fax: +86-411-87402053
Received: September 21, 2009
Revised: October 26, 2009
Accepted: November 3, 2009
Published online: December 7, 2009
Revised: October 26, 2009
Accepted: November 3, 2009
Published online: December 7, 2009
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