Takaaki Ono, Phawinee Subsomwong, Junko Akada, Takashi Matsumoto, Rumiko Suzuki, Yoshio Yamaoka, Department of Environmental and Preventive Medicine, Oita University Faculty of Medicine, Yufu 879-5593, Japan
Takaaki Ono, Criminal Investigation Laboratory, Oita Prefectural Police Headquarters, Oita 870-1117, Japan
Modesto Cruz, Celso Hosking, Institute of Microbiology and Parasitology, IMPA, Faculty of Science, Autonomous University of Santo Domingo, Santo Domingo 10103, Dominican Republic
Modesto Cruz, Department of Biomedical Research, National Institute of Medicine and Diagnostic Imaging, Santo Domingo 10107, Dominican Republic
Hiroyuki Nagashima, Department of Gastroenterology, Hokkaido Cancer Center, Sapporo 003-0804, Japan
Tomohisa Uchida, Department of Molecular Pathology, Oita University Faculty of Medicine, Yufu 879-5593, Japan
José A Jiménez Abreu, Dominican-Japanese Digestive Disease Center, Dr Luis E. Aybar Health and Hygiene City, Santo Domingo 10302, Dominican Republic
Yoshio Yamaoka, Department of Medicine, Gastroenterology and Hepatology Section, Baylor College of Medicine, Houston, TX 77030, United States
Author contributions: Suzuki R, Cruz M and Yamaoka Y conceived and designed the experiments; Ono T, Nagashima H, Subsomwong P and Uchida T performed the experiments; Ono T, Akada J, Matsumoto T, Suzuki R and Yamaoka Y analyzed the data; Cruz M, Hosking C and Jiménez Abreu JA contributed to obtaining the samples; Ono T and Yamaoka Y wrote the manuscript; Yamaoka Y and Cruz M revised the manuscript and added important content.
Supported by The Grants-in-aid for Scientific Research from the Ministry of Education, Culture, Sports, Science, and Technology of Japan, No. 16H05191, No. 221S0002, No. 16H06279, No. 18KK0266 and No. 19H03473; and (partly) the National Fund for Innovation and Development of Science and Technology from the Ministry of Higher Education Science and Technology of the Dominican Republic, No. 2012-2013-2A1-65 and No. 2015-3A1-182 (MC).
Institutional review board statement: The protocol was reviewed and approved by the Ethics Committees of Dr Luis E. Aybar Health and Hygiene City, the Institute of Microbiology and Parasitology, IMPA, Faculty of Sciences, Autonomous University of Santo Domingo, UASD and The National Council of Bioethics in Health, CONABIOS, in the Dominican Republic and Oita University, Faculty of Medicine, Japan.
Institutional animal care and use committee statement: This study did not contain animal experiments.
Conflict-of-interest statement: No conflicts of interest exist.
Data sharing statement: No additional data are available.
ARRIVE guidelines statement: The authors have read the ARRIVE guidelines, and the manuscript was prepared and revised according to the ARRIVE guidelines.
: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Yoshio Yamaoka, MD, PhD, Doctor, Professor, Department of Environmental and Preventive Medicine, Oita University Faculty of Medicine, 1-1 Idaigaoka, Hasama-machi, Yufu 879-5593, Japan. email@example.com
Received: August 1, 2020
Peer-review started: August 1, 2020
First decision: September 30, 2020
Revised: October 10, 2020
Accepted: November 12, 2020
Article in press: November 12, 2020
Published online: December 7, 2020