Published online Nov 28, 2020. doi: 10.3748/wjg.v26.i44.7061
Peer-review started: August 31, 2020
First decision: September 30, 2020
Revised: October 10, 2020
Accepted: October 26, 2020
Article in press: October 26, 2020
Published online: November 28, 2020
In 2018, new cases of hepatobiliary-pancreatic (HBP) cancer reached 1.85 million and identifying high-risk populations has become an urgent public health issue. As one of the important metabolites of the human body, serum uric acid (SUA) is considered to be related to cancer risk, but there is controversy about its role in specific cancers.
Because of the dual effect of SUA on cancer risk, the associations between SUA levels and the HBP cancer risk remain unclear.
To evaluate the associations between SUA levels and incidence of hepatobiliary-pancreatic cancer based on the UK Biobank cohort and to investigate the gender differences.
This is a prospective cohort study from the UK Biobank. We estimated the hazard ratios and 95% confidence intervals between SUA levels and hepatobiliary-pancreatic cancer by using multiple adjusted Cox regression models adjusted for potential confounders. In addition, we also conducted a sensitivity analysis to verify the stability of our results.
We included 444462 participants free of cancer. With a median of 6.6 yrs of follow-up, 920 participants developed liver, gallbladder, biliary tract or pancreatic cancer. The risk of pancreatic cancer increases with the SUA levels; however, after the gender-stratified analysis, the association only occurred among the females. Both too high and too low SUA levels are the risk factors of liver cancer among the males. For gallbladder cancer, the positive association with SUA levels was identified among the males. Regarding biliary tract cancer, there is not sufficient evidence for biliary tract cancer and SUA levels.
SUA is likely to have gender-specific effects on HBP cancer. In clinical and public health practice, controlling SUA levels in an appropriate range may help prevent HBP cancer.
In the future, more research is needed to investigate the association between the SUA levels and other specific-site cancer risk and the underlying mechanism.