Case Control Study
Copyright ©The Author(s) 2019. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastroenterol. Sep 14, 2019; 25(34): 5152-5161
Published online Sep 14, 2019. doi: 10.3748/wjg.v25.i34.5152
Association of XPG rs2094258 polymorphism with gastric cancer prognosis
Xiao-Qin Wang, Paul D Terry, Yang Li, Yue Zhang, Wen-Jing Kou, Ming-Xu Wang
Xiao-Qin Wang, Yang Li, Yue Zhang, Wen-Jing Kou, Ming-Xu Wang, Department of Public Health, Xi’an Jiaotong University Health Science Center, Xi’an 710061, Shaanxi Province, China
Paul D Terry, Graduate School of Medicine, University of Tennessee Medical Center, Knoxville, TN 37920, United States
Author contributions: Wang XQ wrote the manuscript; Wang XQ and Terry PD analyzed the data; Li Y, Zhang Y, and Kou WJ performed the majority of experiments; Wang XQ and Wang MX designed the research; Wang MX and Terry PD revised the manuscript.
Supported by the Fundamental Research Funds for the Central Universities, No. zdyf2017007.
Institutional review board statement: This study was approved by the Institutional Review Board of Health Science Center of Xi’an Jiaotong University.
Informed consent statement: Informed consent was obtained from all study participants.
Conflict-of-interest statement: The authors declare no conflict of interest.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Corresponding author: Ming-Xu Wang, PhD, Professor, Department of Public Health, Xi’an Jiaotong University Health Science Center, 76 Yanta West Road, Xi’an 710061, Shaanxi Province, China. wangmx601@mail.xjtu.edu.cn
Telephone: +86-13991815026 Fax: +86-29-82657517
Received: May 16, 2019
Peer-review started: May 16, 2019
First decision: July 21, 2019
Revised: July 25, 2019
Accepted: August 19, 2019
Article in press: August 19, 2019
Published online: September 14, 2019
Processing time: 119 Days and 20.3 Hours
ARTICLE HIGHLIGHTS
Research background

Gastric cancer (GC) is one of the leading causes of cancer-related death worldwide, which causes a high social and economic burden. Xeroderma pigmentosum group G (XPG) or ERCC5 may play a key role in DNA repair, thus affecting cancer prognosis. Studies have shown that XPG SNPs may affect the development of cancer such as lung cancer, colorectal cancer, and breast cancer.

Research motivation

Only a few studies have explored the relationships between XPG gene SNPs and GC, and the results are inconsistent.

Research objectives

To examine GC risk and survival in relation to common functional XPG SNPs through a case-control study, which might improve our understanding of GC and provide new therapeutic targets for this malignancy.

Research methods

A total of 956 histologically confirmed GC cases and 1012 controls were matched by sex, age (within 5 years), and residential district. Cases were followed and the survival time was recorded. DNA was extracted from peripheral blood samples of all cases and controls. XPG rs2094258, rs751402, rs2296147, rs1047768, and rs873601 polymorphisms were genotyped using PCR-RFLP. Logistic regression and Cox regression were used for analyzing associations of XPG SNPs with risk of GC and prognosis, respectively.

Research results

We found that GC patients with the rs2094258 CT + CC genotype showed a worse survival than those with the TT genotype, and patients with the CC genotype had a tendency of unfavorable prognosis compared with those with the TT + CT genotype. The increase in the number of C alleles of rs2094258 was associated with the long-term survival of GC cases. Other risk factors for survival included tumor differentiation, lymphovascular invasion, and use of chemotherapy. However, the exact mechanisms by which XPG SNPs influence GC survival remain to be solved.

Research conclusions

The XPG rs2094258 polymorphism may be associated with overall survival in patients with GC.

Research perspectives

If confirmed by other studies, the results of our study suggest that XPG rs2094258 polymorphisms may serve as genetic biomarkers for GC prognosis, and may provide clues to biological underpinnings of GC progression.