Ma FH, Xue LY, Chen YT, Xie YB, Zhong YX, Xu Q, Tian YT. Neuroendocrine carcinoma of the gastric stump: A case report and literature review. World J Gastroenterol 2018; 24(4): 543-548 [PMID: 29398875 DOI: 10.3748/wjg.v24.i4.543]
Corresponding Author of This Article
Yan-Tao Tian, MD, Professor, Department of Pancreatic and Gastric Surgery, National Cancer Center/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, No. 17, Panjiayuan Nanli, Beijing 100021, China. tyt67@163.com
Research Domain of This Article
Oncology
Article-Type of This Article
Case Report
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Fu-Hai Ma, Ying-Tai Chen, Yi-Bin Xie, Yu-Xin Zhong, Quan Xu, Yan-Tao Tian, Department of Pancreatic and Gastric Surgery, National Cancer Center/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100021, China
Li-Yan Xue, Department of Pathology, National Cancer Center/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100021, China
Author contributions: Tian YT and Xue LY designed the report; Xie YB, Zhong YX and Xu Q collected the patient’s clinical data; Ma FH and Chen YT analyzed the data and wrote the paper.
Supported by Beijing Municipal Science and Technology Commission, No. 30224801; and National Natural Science Foundation of China, No. 81772647.
Informed consent statement: Consent was obtained from relatives of the patient for publication of this report and any accompanying images.
Conflict-of-interest statement: The authors declare that they have no conflicts of interest.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Correspondence to: Yan-Tao Tian, MD, Professor, Department of Pancreatic and Gastric Surgery, National Cancer Center/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, No. 17, Panjiayuan Nanli, Beijing 100021, China. tyt67@163.com
Telephone: +86-10-87787120 Fax: +86-10-87787120
Received: November 10, 2017 Peer-review started: November 11, 2017 First decision: November 30, 2017 Revised: December 11, 2017 Accepted: December 20, 2017 Article in press: December 20, 2017 Published online: January 28, 2018
ARTICLE HIGHLIGHTS
Case characteristics
The most common form of gastric stump cancer (GSC) is adenocarcinoma. Various types of gastric stump malignancies have been reported previously, but the development of neuroendocrine carcinoma (NEC) from the gastric stump is rare.
Clinical diagnosis
Gastric ulcer.
Differential diagnosis
Gastric cancer and lymphoma.
Laboratory diagnosis
NEC of the gastric stump.
Imaging diagnosis
Neoplasm of the gastric stump.
Pathological diagnosis
NEC of the gastric stump.
Treatment
Surgery combined with chemotherapy and radiotherapy.
Related reports
A case of neuroendocrine carcinoma in the gastric stump has only been reported once in the English literature from the University of Parma, Italy.
Term explanation
Neuroendocrine carcinoma of the gastric stump.
Experiences and lessons
This case will contribute to improvements in our understanding of the carcinogenesis, biology, and behavior of gastric NEC and GSC. This case may also serve as a reminder to gastroenterologists, surgeons, and pathologists who encounter GSC cases in their clinical practice to consider a diagnosis of NEC and undertake the requisite tests for histological and neuroendocrine markers such as chromogranin A and synaptophysin.
