Brief Reports
Copyright ©The Author(s) 2003. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastroenterol. Jul 15, 2003; 9(7): 1598-1600
Published online Jul 15, 2003. doi: 10.3748/wjg.v9.i7.1598
Meta analysis of risk factors for colorectal cancer
Kun Chen, Jiong-Liang Qiu, Yang Zhang, Yu-Wan Zhao
Kun Chen, Jiong-Liang Qiu, Yang Zhang, Yu-Wan Zhao, Department of Epidemiology, School of Medicine, Zhejiang University, Hangzhou 310031, Zhejiang Province, China
Author contributions: All authors contributed equally to the work.
Supported by the National Natural Science Foundation of China, No.30170828
Correspondence to: Kun Chen, Department of Epidemiology, School of Medicine, Zhejiang University, Hangzhou 310031, Zhejiang Province, China. ck@zjuem.zju.edu.cn
Telephone: +86-571-87217190
Received: March 2, 2003
Revised: March 24, 2003
Accepted: April 1, 2003
Published online: July 15, 2003
Abstract

AIM: To study the risk factors for colorectal cancer in China.

METHODS: A meta-analysis of the risk factors of colorectal cancer was conducted for 14 case-control studies, and reviewed 14 reports within 13 years which included 5034 cases and 5205 controls. Dersimonian and Laird random effective models were used to process the results.

RESULTS: Meta analysis of the 14 studies demonstrated that proper physical activites and dietary fibers were protective factors (pooled OR < 0.8), while fecal mucohemorrhage, chronic diarrhea and polyposis were highly associated with colorectal cancer (all pooled OR > 4). The stratified results showed that different OR values of some factors were due to geographic factors or different resourses.

CONCLUSION: Risks of colorectal cancer are significantly associated with the histories of intestinal diseases or relative symptoms, high lipid diet, emotional trauma and family history of cancers. The suitable physical activities and dietary fibers are protective factors.

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