Clinical Research
Copyright ©The Author(s) 2003. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastroenterol. Jul 15, 2003; 9(7): 1580-1583
Published online Jul 15, 2003. doi: 10.3748/wjg.v9.i7.1580
Association of CagA and VacA presence with ulcer and non-ulcer dyspepsia in a Turkish population
Kantarceken Bulent, Aladag Murat, Atik Esin, Koksal Fatih, Harputluoglu MMMurat, Harputluoglu Hakan, Karincaoglu Melih, Ates Mehmet, Yildirim Bulent, Hilmioglu Fatih
Kantarceken Bulent, Aladag Murat, Karincaoglu Melih, Hilmioglu Fatih, Division of Gastroenterology, Medical Faculty, Inonu University, Malatya, Turkey
Atik Esin, Mustafa Kemal University, Department of Pathology, Medical Faculty, Hatay, Turkey
Koksal Fatih, Department of Microbiology, Medical Faculty, Cukurova University, Adana, Turkey
Harputluoglu MMMurat, Ates Mehmet, Division of Gastroenterology, Medical Faculty, Inonu University, Malatya, Turkey
Harputluoglu Hakan, Department of Internal Medicine, Medical Faculty, Inonu University, Malatya, Turkey
Yildirim Bulent, Division of Gastroenterology, Medical Faculty, Inonu University, Malatya, Turkey
Author contributions: All authors contributed equally to the work.
Correspondence to: Bulent Kantarceken, Zafer Mah. Mehmet Buyruk Cad. 2.Ordu karsýsý Hapmbey Apt. Dai. No: 19, 44300/Malatya, Turkey.,
Telephone: +90-422-3411199 Fax: +90-422-3410729(28)
Received: January 14, 2003
Revised: February 4, 2003
Accepted: February 25, 2003
Published online: July 15, 2003

AIM: The mostly known genotypic virulence features, of H. pylori are cytotoxin associated gene A (CagA) and Vacuolating cytotoxin gene A (VacA). We investigated the association of these major virulence factors with ulcer and non-ulcer dyspepsia in our region.

METHODS: One hundred and forty two dyspeptic patients were studied (average age 44.8 ± 15.9 years, range 15-87 years, 64 males and 78 females). Antral and corpus biopsies were taken for detecting and genotyping of H. pylori. 107 patients who were H. pylori positive by histological assessment were divided into three groups according to endoscopic findings: Duodenal ulcer (DU), gastric ulcer (GU) and non-ulcer dyspepsia (NUD). The polymerase chain reaction (PCR) was used to detect CagA and VacA genes of H. pylori using specific primers.

RESULTS: H. pylori was isolated from 75.4% (107/142) of the patients. Of the 107 patients, 66 (61.7%) were CagA-positive and 82 (76.6%) were VacA-positive. CagA gene was positively associated with DU and GU (P < 0.01, P < 0.02), but not with NUD (P > 0.05). Although VacA positivity in ulcer patients was higher than that in NUD group, the difference was not statistically significant (P > 0.05).

CONCLUSION: There is a significantly positive association between CagA genes and DU and GU. The presence of VacA is not a predictive marker for DU, GU, and NUD in our patients.

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