Jin-Lian Chen, Wei-Xiong Chen, Jin-Shui Zhu, Ni-Wei Chen, Department of Gastroenterology, Shanghai Sixth People's Hospital, Shanghai Jiao-Tong University, Shanghai 200233, China
Tong Zhou, Department of Nephrology, Ruijin Hospital, Shanghai Second Medical University, Shanghai 200025, China
Ming-Jun Zhang, Animal Laboratory, Ruijin Hospital, Shanghai Second Medical University, Shanghai 200025, China
Yun-Lin Wu, Department of Gastroenterology, Ruijin Hospital, Shanghai Second Medical University, Shanghai 200025, China
Author contributions: All authors contributed equally to the work.
Supported by the National Natural Science Foundation of China (No.39970340) and the Scientific Foundation of Ministry of Public Health
Correspondence to: Jin-Lian Chen, Department of Gastroenterology, Shanghai Sixth People's Hospital, Shanghai Jiao-Tong University, Shanghai 200233, China. cqinqin@fm365.com
Telephone: +86-21-64369181
Received: December 30, 2002 Revised: February 4, 2003 Accepted: February 19, 2003 Published online: July 15, 2003
Abstract
AIM: To investigate the effect of tetramethylpyrazine on hepatic/renal ischemia and reperfusion injury in rats.
METHODS: Hepatic/renal function, histopathological changes, and hepatic/renal P-selectin expression were studied with biochemical measurement and immunohistochemistry in hepatic/renal ischemia and reperfusion injury in rat models.
RESULTS: Hepatic/renal insufficiency and histopathological damage were much less in the tetramethylpyrazine-treated group than those in the saline-treated groups. Hepatic/renal P-selectin expression was down regulated in the tetramethylpyrazine-treated group.
CONCLUSION: P-selectin might mediate neutrophil infiltration and contribute to hepatic/renal ischemia and reperfusion injury. Tetramethylpyrazine might prevent hepatic/renal damage induced by ischemia and reperfusion injury through inhibition of P-selectin.
