Published online Apr 15, 2003. doi: 10.3748/wjg.v9.i4.741
Revised: July 20, 2002
Accepted: July 27, 2002
Published online: April 15, 2003
AIM: To determine the prevalences of TTV and HGV infections among blood donors and patients with chronic liver disease in Korea, to investigate the association of TTV and HGV infections with blood transfusion, and to assess the correlation between TTV and HGV viremia and hepatic damage.
METHODS: A total of 391 serum samples were examined in this study. Samples were obtained from healthy blood donors (n = 110), hepatitis B surface antigen (HBsAg)-positive donors (n = 112), anti-hepatitis C virus (anti-HCV)-positive donors (n = 69), patients with type B chronic liver disease (n = 81), and patients with type C chronic liver disease (n = 19). TTV DNA was detected using the hemi-nested PCR. HGV RNA was tested using RT-PCR. A history of blood transfusion and serum levels of alanine aminotransferase (ALT) and aspartate aminotransferase (AST) were also determined.
RESULTS: TTV DNA was detected in 8.2% of healthy blood donors, 16.1% of HBsAg-positive donors, 20.3% of anti-HCV-positive donors, 21.0% of patients with type B chronic liver disease, and 21.1% of patients with type C chronic liver disease. HGV RNA was detected in 1.8% of healthy blood donors, 1.8% of HBsAg-positive donors, 17.4% of anti-HCV-positive donors, 13.6% of patients with type B chronic liver disease, and 10.5% of patients with type C chronic liver disease. The prevalence of TTV and HGV infections in HBV- or HCV-positive donors and patients was significantly higher than in healthy blood donors (P < 0.05), except for the detection rate of HGV in HBsAg-positive donors which was the same as for healthy donors. There was a history of transfusion in 66.7% of TTV DNA-positive patients and 76.9% of HGV RNA-positive patients (P < 0.05). No significant increase in serum ALT and AST was detected in the TTV- or HGV-positive donors and patients.
CONCLUSION: TTV and HGV infections are more frequently found in donors and patients infected with HBV or HCV than in healthy blood donors. However, there is no significant association between TTV or HGV infections and liver injury.