Colorectal Cancer
Copyright ©The Author(s) 2003. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastroenterol. Feb 15, 2003; 9(2): 284-287
Published online Feb 15, 2003. doi: 10.3748/wjg.v9.i2.284
Clinical characteristics and diagnosis of patients with hereditary nonpolyposis colorectal cancer
San-Jun Cai, Ye Xu, Guo-Xiang Cai, Peng Lian, Zu-Qing Guan, Shan-Jing Mo, Meng-Hong Sun, Qi Cai, Da-Ren Shi
San-Jun Cai, Ye Xu, Guo-Xiang Cai, Peng Lian, Zu-Qing Guan, Shan-Jing Mo, Department of Abdominal Surgery, Shanghai Cancer Hospital/Institute, Fudan University, Shanghai 200032, China
Meng-Hong Sun, Qi Cai, Da-Ren Shi, Department of Pathology, Shanghai Cancer Hospital/Institute, Fudan University, Shanghai 200032, China
Author contributions: All authors contributed equally to the work.
Supported by Shanghai Medical Development Fund for Major Projects, No. 993025-I
Correspondence to: San-Jun Cai, Department of Abdominal Surgery, Shanghai Cancer Hospital/Institute, Fudan University, Shanghai 200032, China. sanjunc@online.sh.cn
Telephone: +86-21-64175590-2508
Received: August 15, 2002
Revised: September 4, 2002
Accepted: September 12, 2002
Published online: February 15, 2003
Abstract

AIM: To study the clinical characteristics of hereditary nonpolyposis colorectal cancer (HNPCC) in the Chinese population and discuss the identification and management of the patients with HNPCC.

METHODS: A series of 140 patients with colorectal cancers (CRC) and HNPCC associated tumors from 30 families fulfilling the Amsterdam criteria were analyzed.

RESULTS: A total of 118 patients had CRC. Average age at diagnosis of the first CRC was 45.7 years, 56.8% and 23.4% of the first CRC were located proximal to the splenic flexure and in the rectum respectively. Twenty-three (19.5%) had synchronous and metachronous CRC. Twenty-seven patients were found to have extracolonic tumors. Gastric carcinoma was the most common tumor type in our series (44.4%).

CONCLUSION: The frequency of HNPCC was 2.6% in our series of patients. The main features are an excess of early onset with a propensity to involve the proximal colon, and high frequency of multiple foci. Management and surveillance for these patients should be different from sporadic CRC. Contrary to American and European reports, gastric cancer seems more frequent than endometrial cancer in Chinese. It is necessary to formulate a new HNPCC criterion for Chinese patients.

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