Esophageal Cancer
Copyright ©The Author(s) 2003. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastroenterol. Dec 15, 2003; 9(12): 2654-2657
Published online Dec 15, 2003. doi: 10.3748/wjg.v9.i12.2654
Epoxide hydrolase Tyr113His polymorphism is not associated with susceptibility to esophageal squamous cell carcinoma in population of North China
Jian-Hui Zhang, Xia Jin, Yan Li, Rui Wang, Wei Guo, Na Wang, Deng-Gui Wen, Zhi-Feng Chen, Gang Kuang, Li-Zhen Wei, Shi-Jie Wang
Jian-Hui Zhang, Xia Jin, Yan Li, Wei Guo, Na Wang, Deng-Gui Wen, Zhi-Feng Chen, Gang Kuang, Li-Zhen Wei, Shi-Jie Wang, Hebei Cancer Institute, Hebei Medical University, Shijiazhuang 050011, Hebei Province, China
Rui Wang, Shi-Jie Wang, The Fourth Affiliated Hospital, Hebei Medical University, Shijiazhuang 050011, Hebei Province, China
Author contributions: All authors contributed equally to the work.
Supported by the Scientific Grant of Educational Department of Hebei Province, China, No. 2001150
Correspondence to: Professor Shi-Jie Wang, The Fourth Affiliated Hospital, Hebei Medical University, Jiankanglu 12, Shijiazhuang 050011, China. wang.sj@hbmu.edu
Telephone: +86-311-6085231 Fax: +86-311-6077634
Received: June 16, 2003
Revised: June 25, 2003
Accepted: August 25, 2003
Published online: December 15, 2003
Abstract

AIM: To investigate the possible association of microsomal epoxide hydrolase (mEH) Tyr113His polymorphism with susceptibility to esophageal squamous cell carcinoma (ESCC) in a population of North China.

METHODS: The mEH Tyr113His genotypes were determined by polymerase-chain reaction (PCR)-restriction fragment length polymorphism (RFLP) analysis in 257 patients with esophageal squamous cell carcinoma (ESCC) and 252 healthy subjects as a control group.

RESULTS: The frequencies for Tyr and His alleles were 44.2%, 55.8% in ESCC patients, and 44.0% and 56.0% in healthy subjects, respectively. No statistic difference in allele distribution was observed between ESCC patients and controls (χ2 = 0.008, P = 0.929). The overall genotype distribution difference was not observed between cancer cases and controls (χ2 = 2.116, P = 0.347). Compared with Tyr/Tyr genotype, neither His/His genotype nor in combination with Tyr/His genotype significantly modified the risk of the development of ESCC, the adjusted odds ratio was 1.076 (95%CI = 0.850-1.361) and 0.756 (95%CI = 0.493-1.157), respectively. When stratified for sex, age, smoking status and family history of upper gastrointestinal cancer, His/His genotype alone or in combination with Tyr/His genotype also did not show any significant influence on the risk of developing ESCC.

CONCLUSION: MEH Tyr113His polymorphism may not be used as a stratification marker in screening individuals at a high risk of ESCC.

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