Zhao P, Hu YC, Talbot IC. Expressing patterns of p16 and CDK4 correlated to prognosis in colorectal carcinoma. World J Gastroenterol 2003; 9(10): 2202-2206 [PMID: 14562378 DOI: 10.3748/wjg.v9.i10.2202]
Corresponding Author of This Article
Dr. Po Zhao, Department of Pathology, Chinese PLA General Hospital, 28 Fuxing Road, Beijing 100853, China. zhaopo@plagh.com.cn or Professor Ian C. Talbot, Academic Department of Pathology, St Mark’s Hospital, Cancer Research UK, Colorectal Cancer Unit, Watford Road, Harrow HA1 3UJ, London, UK. i.talbot@cancer.org.uk
Article-Type of This Article
Colorectal Cancer
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World J Gastroenterol. Oct 15, 2003; 9(10): 2202-2206 Published online Oct 15, 2003. doi: 10.3748/wjg.v9.i10.2202
Expressing patterns of p16 and CDK4 correlated to prognosis in colorectal carcinoma
Po Zhao, Ying-Chuan Hu, Ian C. Talbot
Po Zhao, Department of Pathology, Chinese PLA General Hospital, Beijing 100853, Beijing, China and Academic Department of Pathology, St. Mark’s Hospital, Cancer Research UK, Colorectal Cancer Unit, Harrow, HA1 3UJ, London, UK
Ying-Chuan Hu, Department of Pathology, Huaxi Medical College, Sichuan University, Chengdu 610041, Sichuan Province, China
Ian C. Talbot, Academic Department of Pathology, St. Mark’s Hospital, Cancer Research UK, Colorectal Cancer Unit, Harrow, HA1 3UJ, London, UK
Author contributions: All authors contributed equally to the work.
Correspondence to: Dr. Po Zhao, Department of Pathology, Chinese PLA General Hospital, 28 Fuxing Road, Beijing 100853, China. zhaopo@plagh.com.cn or Professor Ian C. Talbot, Academic Department of Pathology, St Mark’s Hospital, Cancer Research UK, Colorectal Cancer Unit, Watford Road, Harrow HA1 3UJ, London, UK. i.talbot@cancer.org.uk
Telephone: +86-10-66937954 Fax: +86-10-68181689
Received: March 2, 2003 Revised: May 9, 2003 Accepted: May 16, 2003 Published online: October 15, 2003
Abstract
AIM: To describe the correlation between innunostaining patterns of p16 and CDK4 and prognosis in colorectal carcinoma.
METHODS: Paraffin sections of 74 cases of colorectal carcinoma were analysed immunohistochemically for expression of p16 and CDK4 proteins.
RESULTS: Most carcinomas showed stronger p16 and CDK4 immunostaining in the cytoplasm than the adenomas or the adjacent normal mucosa. Strong immunostaining of p16 was a predictor for better prognosis whereas strong cytoplasmic immunostaining of CDK4 was a predictor for poor prognosis. Both p16 and CDK4 immunostainings were correlated with histological grade or Dukes’ stage.
CONCLUSION: These results support the experimental evidence that interaction of expression of p16 and CDK4 may play an important role in the Rb/p16 pathway, and the expression paterns of CDK4 and p16 may be imperative in the development of colorectal carcinoma, thus becoming a new prognostic marker in colorectal cancer.
