Effect of jianpiyiwei capsule on gastric precancerous lesions in rats

doi:10.3748/wjg.v8.i4.608

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

Gastric Cancer

World J Gastroenterol. Aug 15, 2002; 8(4): 608-612
Published online Aug 15, 2002. doi: 10.3748/wjg.v8.i4.608

Effect of jianpiyiwei capsule on gastric precancerous lesions in rats

Xue-Ying Shi, Feng-Zhi Zhao, Xin Dai, Lian-Sheng Ma, Xiu-Yu Dong, Jie Fang

Xue-Ying Shi, Feng-Zhi Zhao, Xin Dai, Lian-Sheng Ma, Xiu-Yu Dong, Jie Fang, Department of Pathology, Peking University, School of Basic Medical Sciences, Beijing 100083, China

Feng-Zhi Zhao, Xin Dai, Jie Fang, Department of Pathology, Dongzhimen Affiliated Hospital, Beijing University of Traditional Chinese Medicine, Beijing 100700, China

Lian-Sheng Ma, Taiyuan Research & Treatment Center for Digestive Diseases, Taiyuan 030001, Shanxi Province, China

Xiu-Yu Dong, Department of Gastroenterology, Third School of Clinical Medicine, Peking University, School of Medical Sciences, Beijing 100083, China

Author contributions: All authors contributed equally to the work.

Correspondence to: Dr. Lian-Sheng Ma, Taiyuan Research & Treatment Center of Digestive Disease, 77 Shuangta Xiejie, Taiyuan 030001, Shanxi Province China. wcjd@public.public.bta.net.cn

Telephone: +86-10-85381892 Fax: +86-10-85381893

Received: April 9, 2002
Revised: June 12, 2002
Accepted: June 15, 2002
Published online: August 15, 2002

Abstract

AIM: To evaluate the therapeutic effect of compound Chinese drugs, Jianpiyiwei capsule (JPYW) on gastric precancerous lesions in rats and to explore its mechanism of action.

METHODS: Model of gastric precancerous lesions was constructed in male Wistar rats: a metal spring was inserted and fixed through pyloric sphincter. One week after recovery, each rat was given 50-60 °C hot paste containing 150 g/L NaCl 2 mL orally, twice a week for 15 wk. Then 10 normal and 11 model rats were anaesthetized, after the measurement of gastric mucosa blood flow (GMBF), the rats were killed and the mucosal hexosamines and malonic dialdehyde (MDA) were measured. The morphological changes of gastric mucosa were observed macroscopically and microscopically, and by an automatic imaging analysis system. Other rats were treated with JPYW 1.5 g/kg·d^-1 or 4.5 g/kg·d^-1, or distilled water as negative control respectively (n = 10 in each group). After 12 wk, all the rats were examined as above.

RESULTS: The gastric mucosa of model rats showed chronic atrophic gastritis with dysplasia and intestinal metaplasia (IM), GMBF and hexosamine content were reduced significantly and MDA was increased as compared to the normal group (P < 0.01). After 12 wk treatment, the pathological changes of the negative control group became worsened, while in JPYW treated groups the changes were modified with significant increase of GMBF and reduction of MDA, although the hexosamine concentration increased only mildly.

CONCLUSION: JPYW increases GMBF and reduces MDA content in gastric mucosa and has therapeutic effects on gastric precancerous lesions.

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