Copyright ©The Author(s) 2002. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastroenterol. Aug 15, 2002; 8(4): 577-579
Published online Aug 15, 2002. doi: 10.3748/wjg.v8.i4.577
Hepatitis C and HIV co-infection: A review
Irena Maier, George Y. Wu
Irena Maier, George Y. Wu, Department of Medicine, Division of Gastroenterology-Hepatology University of Connecticut Health Center, Farmington, CT 06030-1845, USA
Author contributions: All authors contributed equally to the work.
Correspondence to: George Y. Wu, M.D., Ph.D, Department of Medicine Division of Gastroenterology-Hepatology, University of Connecticut Health Center, Rm. AM-045, 263 Farmington Avenue, Farmington, CT, USA.
Telephone: +1-860-679-3158 Fax: +1-860-679 3159
Received: June 27, 2002
Revised: July 1, 2002
Accepted: July 4, 2002
Published online: August 15, 2002

Co-infection with hepatitis C virus and human immunodeficiency virus is common in certain populations. Among HCV (+) persons, 10% are also HIV (+), and among HIV (+) persons, 25% are also HCV (+). Many studies have shown that in intravenous drug users, co-infection prevalence can be as high as 90%-95%. There is increasing evidence supporting the concept that people infected with HIV have a much more rapid course of their hepatitis C infection. Treatment of co-infection is often challenging because highly active anti-retroviral therapy (HAART) therapy is frequently hepatotoxic, especially in the presence of HCV. The purpose of this review is to describe the effects that HIV has on hepatitis C, the effects that hepatitis C has on HIV, and the treatment options in this challenging population.

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