Liver Cancer
Copyright ©The Author(s) 2002. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastroenterol. Feb 15, 2002; 8(1): 79-81
Published online Feb 15, 2002. doi: 10.3748/wjg.v8.i1.79
Anti-hepatoma activity of resveratrol in vitro
Zhong-Jie Sun, Cheng-En Pan, Hong-Shan Liu, Guo-Jun Wang
Zhong-Jie Sun, Cheng-En Pan, Hong-Shan Liu, Guo-Jun Wang, Department of Hepatobiliary Surgery, First Hospital of Xi’an Jiaotong University, Xi’an 710061, Shaanxi Province, China
Author contributions: All authors contributed equally to the work.
Correspondence to: Dr. Zhong-Jie SUN, Department of Hepatobiliary Surgery, First Hospital of Xi’an Jiaotong University Xi’an 710061, Shaanxi Province, China. szhjie@21cn.com
Telephone: +86-029-5260273 Fax: +86-029-5260273
Received: August 9, 2001
Revised: August 20, 2001
Accepted: August 23, 2001
Published online: February 15, 2002
Abstract

AIM: To study the anti-tumor effect of resveratrol alone and the synergistic effects of resveratrol with 5-FU on the growth of H22 cells line in vitro

METHODS: The number of cells was measured by MTT method,the morphological changes of H22 cells were investigated under microscopy and electron microscopyq.

RESULTS: Resveratrol inhibited the growth of hepatoma cells line H22 in a dose- and time-dependent manner. IC50 of the resveratrol on H22 cells was 6.57 mg·L-1. The synergistic anti-tumor effects of resveratrol with 5-FU increased to a greater extent than for H22 cells treated with 5-FU alone (70.2% vs 28.4%)(P < 0.05). Under microscope and electron microscope, characteristics of apoptosis such as typical apoptotic bodies were commonly found in tumor cells in the drug-treated groups.

CONCLUSION: Resveratrol can suppresses the growth of H22 cells in vitro, its anti-tumor activity may occur through the induction of apoptosis.

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