Brief Report
Copyright ©The Author(s) 2001. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastroenterol. Aug 15, 2001; 7(4): 587-592
Published online Aug 15, 2001. doi: 10.3748/wjg.v7.i4.587
Treatment of malignant digestive tract obstruction by combined intraluminal stent installation and intra-arterial drug infusion
Ai-Wu Mao, Zhong-Du Gao, Jia-Yu Xu, Ren-Jie Yang, Xiang-Seng Xiao, Ting-Hui Jiang, Wei-Jun Jiang
Ai-Wu Mao, Zhong-Du Gao, Ting-Hui Jiang, Wei-Jun Jiang, Department of Interventional Radiology, Shanghai S. T, Luke’s Hospital, 768 Yu Yuan Road, Shanghai 200050, China
Jia-Yu Xu, Department of Gastroenterology Rui Jin Hospital, Shanghai Second Medical University
Ren-Jie Yang, Department of Tumor Hospital, Beijing Medical University
Xiang-Seng Xiao, Department of Imaging Chang Zheng Hospital, Shanghai Second Military Medical University
Author contributions: All authors contributed equally to the work.
Correspondence to: Ai-Wu Mao, Department of Interventional Radiology, Shanghai S.T, Luke’s Hospital, 768 Yu Yuan Road, Shanghai 200050, China. maw1@elong.com.
Telephone: 0086-21-62524259 Ext. 3397 Fax: 0086-21-62113884
Received: March 12, 2001
Revised: June 8, 2001
Accepted: June 15, 2001
Published online: August 15, 2001
Abstract

AIM: To study the palliative treatment of malignant obstrution of digestive tract with placement of intraluminal stent combined with intra-arterial infusion of chemotherapeutic drugs.

METHODS: A total of 281 cases of digestive tract malignant obstruction were given per oral (esophagus, stomach, duodenum and jejunum), per anal (colon and rectum) and percutaneous transhepatic (biliary) installation of metallic stent. Among them, 203 cases received drug infusion by cannulation of tumor supplying artery with Seldinger’s technique.

RESULTS: Altogether 350 stents were installed in 281 cases, obstructive symptoms were relieved or ameliorated after installation. Occurrence of restenotic obstruction was 8-43 weeks among those with intra-arterial drug infusion, which was later than 4-26 weeks in the group with only stent installation. The average survival time of the former group was 43 (3-105) weeks, which was significantly longer than 13 (3-24) weeks of the latter group.

CONCLUSION: Intraluminal placement of stent combined with intra-arterial infusion chemotherapy is one of the effective palliative therapies for malignant obstruction of the digestive tract with symptomatic as well as etiological treatment.

Keywords: digestive tract disease; treatment; stent; therapeutic embolization chemotherapy; infusion, local