Original Articles
Copyright ©The Author(s) 1999. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastroenterol. Aug 15, 1999; 5(4): 308-311
Published online Aug 15, 1999. doi: 10.3748/wjg.v5.i4.308
Effects of a bioartificial liver support system on acetaminophen induced acute liver failure canines
Yi-Long Xue, Shi-Feng Zhao, Zuo-Yun Zhang, Yue-Feng Wang, Xin-Jian Li, Xiao-Qiang Huang, Yun Luo, Ying-Cai Huang, Cheng-Gui Liu
Yi-Long Xue, Zuo-Yun Zhang, Yue-Feng Wang, Xin-Jian Li, Cheng-Gui Liu, Yun Luo, Institute of Basic Medical Sciences, PLA General Hospital, Beijing 100853, China
Shi-Feng Zhao, Department of Emergency, PLA General Hospital, Beijing 100853, China
Xiao-Qiang Huang, Department of Hepatobiliary Surgery, PLA General Hospital, Beijing 100853, China
Ying-Cai Huang, Department of Digestion, PLA General Hospital, Beijing 100853, China
Author contributions: All authors contributed equally to the work.
Supported by the Scientific Research Fund of Ministry of Education for Ouerseas Chinese Fellows who Returned Home, No. 94-001 and Hong Kong TECA LTD Co
Correspondence to: Dr. Yi-Long Xue, Institute of Basic Medical Science, PLA General Hospital, Beijing 100853, China. xueyl@plagh.com.cn
Telephone: +86-10-66937914
Received: April 28, 1999
Revised: July 3, 1999
Accepted: July 19, 1999
Published online: August 15, 1999
Abstract

AIM: To evaluate the safety and efficacy of the bioartificial liver support system in canines with acute liver failure (ALF).

METHODS: Nine canines with acute liver failure by acetaminophen -induced received TECA- I bioartificial liver support system (BALSS) from Hong Kong TECA LTD Co. Blood was perfused through a hollow fiber tube containing (1.2) × 1010 the porcine hepatocytes. In contrast, another 10 canines with a cute liver failure by Acetaminophen received drugs. Each treatment lasted 6 h.

RESULTS: BALSS treatment resulted in beneficial effects for acetaminophen-induced ALF canines with survival and with the recovery of the live r functions and tissues, and plasma ammonia decreased from 135.9 μmol/L ± 17.5 μmol/L to 65.7 μmol/L ± 22.0 μmol/L, 32.5 μmol/L ± 8.8 μmol/L, GPT from 97.8 U/L ± 8.7 U/L to 64.8 U/L ± 11.9 U/L, 19.0 U/L ± 6.3 U/L, GOT from 103.0 U/L ± 16.7 U/L to 75.7 U/L ± 19.6 U/L, 26.5 U/L ± 5.0 U/L, and AKP from 158.3 U/L ± 12.1 U/L to 114.5 U/L ± 19.8 U/L, 43.8 U/L ± 5.6 U/L during and after the treatment. In contrast, 10 ALF canines in both the drug and control groups died 1 or 2 d after treatment.

CONCLUSION: TECA-1 artificial liver support system is safe and efficacious for canines with acute liver failure.

Keywords: liver support system, acute liver failure, canines, porcine hepatocytes, bioartificial liver, acetaminophen