Original Articles
Copyright ©The Author(s) 1999. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastroenterol. Jun 15, 1999; 5(3): 231-234
Published online Jun 15, 1999. doi: 10.3748/wjg.v5.i3.231
Studies on the flow and distribution of leukocytes in mesentery microcirculation of rats
Yong Jiang, Ai-Hua Liu, Ke-Seng Zhao
Yong Jiang, Ai-Hua Liu, Ke-Seng Zhao, Chinese PLA Key Laboratory for Shock and Microcirculation, The First Military medical University Guangzhou 510515, China
Yong Jiang, male born on 1964-10-25 in Henan Province, graduated and got a Ph.D. degree from the Academy of Military Medical Sciences in 1997, now professor of pathophysiology, majoring shock and cellular signal transduction, having more than 50 papers published in international or national major journals .
Author contributions: All authors contributed equally to the work.
Correspondence to: Dr Yong Jiang, Chinese PLA Key Laboratory for Shock and Microcirculation, The First Military Medical University, Guangzhou 510515, China.
Telephone: +86-20-85148376 Fax: +86-20-87705671
Received: January 20, 1999
Revised: February 18, 1999
Accepted: March 6, 1999
Published online: June 15, 1999
Abstract

AIM: To study the effect of leukocyte-endothelium interaction (LEI) on the flow and distribution of leukocytes in microcirculation under physiological condition.

METHODS: A microcirculation image multiple parameter computer analysis system (MIMPCAS) was used to study the flow and distribution of leukocytes in mesentery microcirculation of rats in vivo.

RESULTS: The difference of visible leukocyte flux (VLF) was as high as 131 times in the arterioles and venules with similar diameter and blood velocity. The visible leukocytes rolled along the blood vessel wall as a “jerky” movement. The frequency distribution of the visible leukocyte velocity (VLV) showed a “two-peak” curve. The low peak value was on 10 μm/s-15 μm/s while the high peak fell between 25 μm/s-30 μm/s. With the increase of diameter of venules, VLF increased while the VLV remained at the same level. With the increase of RBC velocity, VLV trends to elevate and VLF to fall down.

CONCLUSION: The results herein might provide a basic theory for the study on the mechanism of LEI under physiological condition and novel methods for the prevention and treatment of high LEI in many pathological processes.

Keywords: microcirculation; leukocyte; leukocyte-endothelium interaction; mesentery