Combined Traditional And Modern Medicine
Copyright ©The Author(s) 1999. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastroenterol. Feb 15, 1999; 5(1): 61-63
Published online Feb 15, 1999. doi: 10.3748/wjg.v5.i1.61
Plasma L-ENK, AVP, ANP and serum gastrin in patients with syndrome of Liver-Qi-stagnation
Ze-Qi Chen, Guo-Lin Chen, Xue-Wen Li, Yu-Qiu Zhao, Lin-Jie Shi
Ze-Qi Chen, Guo-Lin Chen, Xue-Wen Li, Yu-Qiu Zhao, Lin-Jie Shi, Department of TCM, Affiliated Xiangya Hospital, Hunan Medical Uni-versity, Changsha 410008, Hunan Province, China
Ze-Qi Chen, male, born on 1951-10-04, in Ningxiang County, Hunan Province, graduated from Hunan Medical University in 1973, now associate professor, Deputy Chief Physician of Department of In-tegrated Chinese and Western Medicine, majoring in liver disease study in TCM (Traditional Chinese Medicine), having 30 papers published.
Author contributions: All authors contributed equally to the work.
Supported by the National Natural Science Foundation of China, No.39330240
Correspondence to: Dr. Ze-Qi Chen, Department of TCM, Affiliated Xiangya Hospital, Hunan Medical University, 141 Xiangya Road, Changsha 410008 , Hunan Province, China
Received: July 6, 1998
Revised: November 22, 1998
Accepted: December 13, 1998
Published online: February 15, 1999

AIM To investigate the pathophysiologic basis of syndrome of Liver-Qi stagnation and parame-ters for clinical differentiation.

METHODS Plasma L-ENK, AVP, ANP and serum gastrin were determined by RIA in 84 patients with neurasthenia, mastodynia, chronic gastri-tis, and chronic cholecystitis presenting the same syndrome of Liver-Qi stagnation in tr adi-tional Chinese medicine (TCM). Healthy subjects served as controls in comparison with patients having the same syndrome but with different diseases.

RESULTS Among the patients with Liver-Qi stagnation, the plasma L-ENK, ANP and gastrin levels were 38.83 ng/L ± 6.32 ng/L, 104.11 ng/L ± 29.01 ng/L and 32.20 ng/L ± 6.68 ng/L, being significantly lower than those in the healthy controls (P < 0.01, t = 3.34, 6.17, 4.48). The plasma AVP of the patient group (52.82 ng/L ± 19.09 ng/L) was significantly higher than that of the healthy contr ols (P < 0.01, t = 5.79). The above changes in patients having the same symptom complex but different diseases entities showed no significant differences, P > 0.05.

CONCLUSION The syndrome of Liver-Qi stagnation is closely related to the emotional modulatory abnormality of the brain, with decrease of plasma L-ENK, ANP and gastrin, and increase of plasma AVP as the important pathophysiologic basis.

Keywords: Syndrome of Liver-Qi stagna-tion, leucine enkephalin/ blood, arginine vaso-pressin/ blood, atrial natural polypeptide/ blood, gastrin/blood