Published online Feb 15, 1999. doi: 10.3748/wjg.v5.i1.10
Revised: October 22, 1998
Accepted: November 6, 1998
Published online: February 15, 1999
AIM To evaluate the relationship between the expression of Ki-67 antigen and the pathobiologi-cal behaviours of gastric cancers especially their distant metastases.
METHODS Fifty-six specimens of gastric cancer routinely fixed in formalin and embedded in paraffin (FFEP) were studied by immunohisto-chemical method.
RESULTS Expression of Ki-67 antigen was sig-nificantly related to the distant metastases to liver, ovary and adrenal gland (P < 0.01), but not related to the histological type, growth pattern, depth of invasion, histological differentiation and the metastases to local lymph nodes (P > 0.05). Furthermore, the Ki-67 antigen expression was significantly related to the DNA aneu-ploidy pattern, which is closely related to poor prognosis (P < 0.05).
CONCLUSION Overexpression of Ki-67 can be used as an objective marker of the proliferative activity for predicting prognosis of gastric can-cer and metastatic potential to distant organs.