Original Articles
Copyright ©The Author(s) 1999. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastroenterol. Feb 15, 1999; 5(1): 10-11
Published online Feb 15, 1999. doi: 10.3748/wjg.v5.i1.10
Relationship between DNA ploidy, expression of ki-67 antigen and gastric cancer metastasis
Lei Xu, Su-Min Zhang, Yan-Ping Wang, Feng-Kai Zhao, Dong-Ying Wu, Yan Xin
Lei Xu, Su-Min Zhang, Yan-Ping Wang, Feng-Kai Zhao, Dong-Ying Wu, Yan Xin, Cancer Institute, China Medical University, Shenyang 110001, China
Lei Xu, female, born on 1970-09-04 in Shenyang City, Liaoning Province, graduated from China Medical University in 1993, doctor and research assistant, majoring gastrointestinal pathology, having 2 papers published.
Author contributions: All authors contributed equally to the work.
Supported by the National Natural Science Foundation of China, No.39370772.
Correspondence to: Dr. Lei Xu, Cancer institute, China Medical Uni-versity, 155 Nanjing Beijie, Shenyang 110001, Liaoning Province, China
Telephone: +86-24-3863731 Ext. 6351
Received: September 15, 1998
Revised: October 22, 1998
Accepted: November 6, 1998
Published online: February 15, 1999

AIM To evaluate the relationship between the expression of Ki-67 antigen and the pathobiologi-cal behaviours of gastric cancers especially their distant metastases.

METHODS Fifty-six specimens of gastric cancer routinely fixed in formalin and embedded in paraffin (FFEP) were studied by immunohisto-chemical method.

RESULTS Expression of Ki-67 antigen was sig-nificantly related to the distant metastases to liver, ovary and adrenal gland (P < 0.01), but not related to the histological type, growth pattern, depth of invasion, histological differentiation and the metastases to local lymph nodes (P > 0.05). Furthermore, the Ki-67 antigen expression was significantly related to the DNA aneu-ploidy pattern, which is closely related to poor prognosis (P < 0.05).

CONCLUSION Overexpression of Ki-67 can be used as an objective marker of the proliferative activity for predicting prognosis of gastric can-cer and metastatic potential to distant organs.

Keywords: Ki-67 antigen, neoplasms metastasis, immunoc hemistry, DNA ploidy, stom-ach neoplasms/pathology