Original Articles
Copyright ©The Author(s) 1998. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastroenterol. Dec 15, 1998; 4(6): 519-523
Published online Dec 15, 1998. doi: 10.3748/wjg.v4.i6.519
Experimental study on mechanism and protection of stress ulcer produced by explosive noise
Guo-Shi Liu, Yu-Xin Huang, Shuan-Wei Li, Bo-Rong Pan, Xin Wang, Da-Yong Sun, Qing-Li Wang
Guo-Shi Liu, Yu-Xin Huang, Xin Wang, Da-Yong Sun, Department of Gastroenterology, Tangdu Hospital, Xi’an 710038, Shaanxi Province, China
Bo-Rong Pan, Room 12, Building 621, the Fourth Military Medical University, Xi’an 710038, Shaanxi Province, China
Shuan-Wei Li, Qing-Li Wang, Department of Gastroenterology, Chinese PLA 371 Hospital, Xinxiang 453000, Henan Province, China
Guo-Shi Liu, male, born on June 29, 1961 and graduated from Bethune Medical University in 1985, having 10 papers published.
Author contributions: All authors contributed equally to the work.
Correspondence to: Dr. Guo-Shi Liu, Department of Gastroenterology, Armed Police Headquarters Hospital, Jilin Province, 46 Nongan South Street, Changchun 130052, Jilin province, China
Received: May 18, 1998
Revised: August 20, 1998
Accepted: November 5, 1998
Published online: December 15, 1998

AIM: To establish an experimental model of stress ulcer produced by explosive noise, and to probe into its mechanism and protection.

METHODS: The country standard Wistar white rats were randomly divided into control group (n = 8), which were neither stimulated nor protected, and stimulating group (divided into subgroups A, B and C, including 8 rats each which were decapitated to draw blood for test immediately, 12 h and 24 h after stimulation) and prevention group (divided into subgroups A, B and C, having 8 rats each, subgroup A was given cimetidine, B anisodamine and C both drugs). Firing noises of submachine guns were used as inflicting factor. The rats were fasted for 24 h and stimulated by firing noise for 12 h. The change of ulcer index, gastric mucosal and related serum hormones were observed.

RESULTS: Stress ulcer was significant in the stimulating group, and its ulcer index (8.6 ± 0.6) was remarkably higher than that in both the control group and prevention group (0.3 ± 0.1, P < 0.01). Its serum gastrin (Gas ng/L, 294 ± 163 vs 63 ± 40, P < 0.01) and endothelin (ET ng/L, 181 ± 57 vs 135 ± 42, P < 0.1) were apparently higher than those in the control group, and its serum nitric oxide (NO) level was conspicuously lower than that in the control group (ng/L, 0.2 ± 0.1 vs 0.8 ± 0.5 P < 0.5), while the serum gastrin level (ng/L, 556 ± 225) in prevention group was distinctly higher than that in both the control (P < 0.01) and stimulating group (P < 0.05). There were no significant differences in the changes of ET and NO between the control and the stimulating groups.

CONCLUSION: Stress ulcer model of rats can be successfully established by the stimulation of explosive noise. Gas, ET and NO are related to the formation of stress ulcer, and play an important role in its mechanism. Hepatic function affected by noise is observed in this experiment.

Keywords: stomach ulcer/etiology, stomach ulcer/prevention and control, gastric mucosa/pathology, noise/advers effects, stress ulcer