Lu MD, Yin YY, Ren W. Study of portal vein embolization with absolute ethanol injection in cirrhotic rats. World J Gastroenterol 1998; 4(5): 415-417 [PMID: 11819334 DOI: 10.3748/wjg.v4.i5.415]
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Dr. Ming-De Lu, Department of Hepatobiliary Surgery, the First Affiliated Hospital, Sun Yat-Sen University of Medical Sciences, Guangzhou 510080, Guangdong Province, China
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World J Gastroenterol. Oct 15, 1998; 4(5): 415-417 Published online Oct 15, 1998. doi: 10.3748/wjg.v4.i5.415
Study of portal vein embolization with absolute ethanol injection in cirrhotic rats
Ming-De Lu, Yiao-Yu Yin, Wei Ren
Ming-De Lu, Yiao-Yu Yin, Wei Ren, Department of Hepatobiliary Surgery, the First Affiliated Hospital, Sun Yat-Sen University of Medical Sciences, Guangzhou 510080, Guangdong Province, China
Ming-De Lu, male, born on 1951-03-25 in Hunan Province, graduated from Sun Yat-Sen University and earned Doctoral Degree (DMSc) from Kyushuo University (Japan), now professor and director of Department of Surgery, majoring hepatobiliary surgery, having 70 papers published.
Author contributions: All authors contributed equally to the work.
Correspondence to: Dr. Ming-De Lu, Department of Hepatobiliary Surgery, the First Affiliated Hospital, Sun Yat-Sen University of Medical Sciences, Guangzhou 510080, Guangdong Province, China
Received: May 6, 1998 Revised: June 23, 1998 Accepted: July 26, 1998 Published online: October 15, 1998
Abstract
AIM: To investigate the effects of portal vein embolization (PVE) with absolute ethanol injection on the cirrhotic livers.
METHODS: Absolute ethanol was injected intraportally into normal and cirrhotic SD rats and the changes of the animals in anatomy, pathology, liver function as well as portal hemodynamics were observed.
RESULTS: At a dose of 0.05mL/ 100g of ethanol, the survival rate was 100% in normal rats compared with 40.9% in cirrhotic rats. PVE in the cirrhotic rats with 0.03 mL/100 g of ethanol, caused significant hypertrophy in non-embolized lobes, mild or moderate damage to the hepatic parenchyma, slight and transient alterations in liver function, portal pressure and portal flow.
CONCLUSION: PVE with absolute ethanol injection in the setting of liver cirrhosis could be safe at an appropriate dose, and precautions aimed at preserving liver function were preferable.
