Combined Traditional and Modera Medicine
Copyright ©The Author(s) 1998. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastroenterol. Aug 15, 1998; 4(4): 348-353
Published online Aug 15, 1998. doi: 10.3748/wjg.v4.i4.348
Effects of Fuzheng Huayu 319 recipe on liver fibrosis in chronic hepatitis B
Ping Liu, Cheng Liu, Lie-Ming Xu, Yi-Yang Hu, Hui-Ming Xue, Cheng-Hai Liu, Zhi-Qing Zhang
Ping Liu, Cheng Liu, Lie-Ming Xu, Yi-Yang Hu, Hui-Ming Xue, Cheng-Hai Liu, Institute of Liver Diseases, Shanghai Academy of Traditional Chinese Medicine, Shanghai 200032, China
Zhi-Qing Zhang, The Third Huaiyin City Hospital, Huaiyin 223300, Jiangsu Province, China
Ping Liu, M.D. & Ph.D., male, born on August 10, 1953 in Lianyungang city, Jiangsu Province, graduated from Shanghai University of TCM as Ph.D. in 1986, professor of hepatology, specialized in hepatology, having 45 papers and 3 books published.
Author contributions: All authors contributed equally to the work.
Correspondence to: Prof. Ping Liu, Institute of Liver Diseases, Shanghai Academy of Traditional Chinese Medicine, 530# LingLing Rd, Shanghai 200032, China
Telephone: +86-21-64036889
Received: December 18, 1997
Revised: January 20, 1998
Accepted: February 19, 1998
Published online: August 15, 1998
Abstract

AIM: To investigate clinic effects of Fuzheng Huayu 319 recipe (319 recipe) on liver fibrosis in chronic hepatitis B.

METHODS: Ninety-five patients with chronic hepatitis B were divide into the treated (63 cases) and control (32 cases) group, and orally administrated with 0.5g 319 capsule or 0.5g Dahuang Zhachong pill tid for 3 months, respectively. The liver functions and serological fibrotic markers were observed before and after treatment, 12 cases in the treated group were examined with liver biopsy.

RESULTS: Three hundreds nineteen recipe could remarkably decreased serum ALT level and total bilirubin and significantly improve serum albumin and A/G ratio. Its effects were better than Dahuang Zhachong pill. Before treatment, patients¡äserum monamine oxidase activities, tissue inhibitor of metalloproteinase (TIMP)-1, procollagen type III and laminin were all higher than those of health peoples. These levels decreased remarkably after treatment, and urine hydroxyproline level increased significantly (P<0.001-0.05). Compared with the control, the improvement in treated group was better than that in the control except TIMP-1. According to the scoring system for staging of chronic hepatitis, the fibrotic extents of 7 cases among 12 cases examined by liver biopsy decreased remarkably (1 case decreased by 3 scores, 5 by 2 scores, 1 by 1 score).

CONCLUSION: Fuzheng Huayu 319 recipe had good therapeutic effects on chronic hepatitis B, it could reverse the development of liver fibross to some extent. In general its effects were better than that of Dahuang Zhachong pill.

Keywords: liver cirrhosis/therapy; hepatitis B; Fuzheng Huayu; procollagen; hyaluronic acid; metalloproteinases; hydroxyproline