Published online Jun 15, 1998. doi: 10.3748/wjg.v4.i3.231
Revised: February 25, 1998
Accepted: April 20, 1998
Published online: June 15, 1998
AIM: To investigate the role of telomeric association in the development of esophageal cancer.
METHODS: Using chromosome R banding technique,telomeric association of chromosome in peripheral blood lymphocytes from 16 untreated patients with esophageal squamous cell carcinoma were observed and 16 healthy adults served as controls.
RESULTS: The teloemeric association frequencies of cell and chromosomes were significantly higher than those of controls (χ2 = 9.56, P < 0.01), but its distribution on the chromosome showed no significant difference (χ2 = 1.01, P > 0.05) between the two groups.
CONCLUSION: Chromosomal instability can be initiated by telomeric associations, and sequential chromosome analysis can aid the understanding of the tumor occurrence and progression.