Published online Jun 15, 1998. doi: 10.3748/wjg.v4.i3.228
Revised: March 26, 1998
Accepted: May 5, 1998
Published online: June 15, 1998
AIM: To further study the role of bcl-2 protein expression in gastric carcinogenesis and tumor progression.
METHODS: Using immunohistochemical staining, the bcl-2 protein expression in 50 cases of gastric carcinoma and its relation to clinical status and pathomorphological parameters were observed.
RESULTS: Forty-one (82%) cases were positive for bcl-2 protein staining which was located in the cytoplasm and nuclear membrane of tumor cells. The rate of bcl-2 protein expression was not correlated with the patient, sex, tumor size, lymph node status or clinical stages (P > 0.05). It was strongly associated with intestinal-type tumors and poorly differentiated tumors (P < 0.05 and P < 0.01).
CONCLUSION: Aberrant bcl-2 protein expression appears to be specifically associated with development of intestinal-type gastric carcinoma, bcl-2 protein expression might play an important role in the early development/promotion and phenotypic differentiation of gastric carcinomas, but not in tumor progression.