Wang CH, Liu F, Ji XH, Li LS, Chai NL. Clinical characteristics and endoscopic management of inflammatory fibroid polyp of the gastrointestinal tract. World J Gastroenterol 2026; 32(42): 120663 [DOI: 10.3748/wjg.120663]
Corresponding Author of This Article
Ning-Li Chai, MD, Chief Physician, Professor, Department of Gastroenterology, The First Medical Center of Chinese PLA General Hospital, No. 28 Fuxing Road, Haidian District, Beijing 100853, China. chainingli@vip.163.com
Research Domain of This Article
Gastroenterology & Hepatology
Article-Type of This Article
research-article
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Share the Article
Wang CH, Liu F, Ji XH, Li LS, Chai NL. Clinical characteristics and endoscopic management of inflammatory fibroid polyp of the gastrointestinal tract. World J Gastroenterol 2026; 32(42): 120663 [DOI: 10.3748/wjg.120663]
World J Gastroenterol. Nov 14, 2026; 32(42): 120663 Published online Nov 14, 2026. doi: 10.3748/wjg.120663
Clinical characteristics and endoscopic management of inflammatory fibroid polyp of the gastrointestinal tract
Chen-Huan Wang, Fang Liu, Xin-Hua Ji, Long-Song Li, Ning-Li Chai
Chen-Huan Wang, Department of Gastroenterology and Hepatology, The First Medical Center, Chinese People’s Liberation Army General Hospital, Beijing 100853, China
Fang Liu, Long-Song Li, Ning-Li Chai, Department of Gastroenterology, The First Medical Center of Chinese PLA General Hospital, Beijing 100853, China
Xin-Hua Ji, Department of Pathology, The First Medical Center, Chinese People’s Liberation Army General Hospital, Beijing 100853, China
Co-first authors: Chen-Huan Wang and Fang Liu.
Co-corresponding authors: Long-Song Li and Ning-Li Chai.
Author contributions: Wang CH and Liu F contributed equally to this article, they are the co-first authors of this manuscript; Wang CH, Liu F, and Ji XH collected the data and conducted follow-up; Wang CH drafted the initial manuscript; Li LS and Chai NL critically revised the manuscript for important intellectual content and finally approved the version to be published, they contributed equally to this article, they are the co-corresponding authors of this manuscript; and all authors reviewed and approved the final manuscript.
Institutional review board statement: This study was approved by the Medical Ethics Committee of Chinese People’s Liberation Army General Hospital, approval No. S2023-115-01.
Informed consent statement: Informed consent was obtained from all individual participants included in the study.
Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.
Data sharing statement: The datasets analyzed during the current study are not publicly available due to data security policy but are available from the corresponding author on reasonable request.
Corresponding author: Ning-Li Chai, MD, Chief Physician, Professor, Department of Gastroenterology, The First Medical Center of Chinese PLA General Hospital, No. 28 Fuxing Road, Haidian District, Beijing 100853, China. chainingli@vip.163.com
Received: March 5, 2026 Revised: April 1, 2026 Accepted: May 6, 2026 Published online: November 14, 2026 Processing time: 201 Days and 15.3 Hours
Abstract
BACKGROUND
Inflammatory fibroid polyps (IFPs) are rare lesions of the gastrointestinal tract. Knowledge regarding the endoscopic and clinical characteristics of IFPs remains limited.
AIM
To investigate the clinical and endoscopic characteristics of IFPs and evaluate the outcomes of endoscopic resection (ER) for IFP management.
METHODS
This retrospective analysis enrolled a consecutive cohort of patients who received ER for IFPs at our institution between March 2014 and December 2024. We collected and analyzed their clinicopathological characteristics, endoscopic findings, and long-term follow-up outcomes.
RESULTS
A total of 108 consecutive patients were included (59 females, 54.6%), with a mean age of 54.6 ± 10.7 years. The median lesion size was 10 mm (range 5-50 mm). Most lesions were located in the stomach (70/108, 64.8%), followed by the large intestine (36/108, 33.3%); one lesion was found in the esophagus and one in the duodenum. All 108 patients successfully underwent ER, with no severe adverse events reported. Both the en bloc resection rate and the endoscopic complete resection rate were 99.1%. Three of 108 patients (2.8%) developed recurrent lesions postoperatively. A comparative analysis of gastric and colorectal IFP patients revealed significant differences in lesion size, endoscopic techniques, and operative time. One case of early gastric cancer coexisting with IFP was identified.
CONCLUSION
IFPs lack specific clinical manifestations and endoscopic findings. ER is safe and effective for the management of IFP, avoiding the need for surgery.
Core Tip: Inflammatory fibroid polyps (IFPs) are rare gastrointestinal mesenchymal lesions with non-specific clinical and endoscopic features. This largest single-center cohort study of endoscopically treated IFPs confirms that ER is a safe and effective first-line treatment for IFPs, with high en bloc and complete resection rates. IFPs also show no specific features under endoscopic ultrasonography. Gastric IFPs tend to be larger and require more complex endoscopic resection techniques than colorectal IFPs.
