Carbonated soft drink for gastric preparation for magnetically controlled capsule endoscopy: An open-label randomized controlled trial
Jia-Hui Zhu, Xiao Liu, Wei Zhou, Xiao-Nan Xu, Wen-Da Sheng, Yi-Lin Han, Xiao-Ou Qiu, Ya-Wei Liu, Yang-Yang Qian, Zhuan Liao, Zhao-Shen Li
Jia-Hui Zhu, Department of Gastroenterology and Endoscopy, Eastern Hepatobiliary Surgery Hospital, The Naval Medical University, Shanghai 200438, China
Jia-Hui Zhu, Xiao Liu, Wei Zhou, Xiao-Nan Xu, Wen-Da Sheng, Yi-Lin Han, Xiao-Ou Qiu, Yang-Yang Qian, Zhuan Liao, Zhao-Shen Li, Department of Digestive Diseases, National Clinical Research Center, Shanghai 200433, China
Xiao Liu, Wei Zhou, Xiao-Nan Xu, Wen-Da Sheng, Yi-Lin Han, Xiao-Ou Qiu, Yang-Yang Qian, Zhuan Liao, Zhao-Shen Li, Department of Gastroenterology, Changhai Hospital, The Naval Medical University, Shanghai 200433, China
Ya-Wei Liu, Department of Gastroenterology, The First Medical Center of Chinese PLA General Hospital/Chinese PLA Postgraduate Military Medical School, Beijing 100039, China
Co-first authors: Jia-Hui Zhu and Xiao Liu.
Co-corresponding authors: Yang-Yang Qian and Zhuan Liao.
Author contributions: Liao Z and Qian YY contributed to funding acquisition, conceptualization and project administration; Zhu JH, Liu X and Qian YY contributed to methodology and formal analysis; Zhu JH, Liu X, Zhou W, Xu XN, and Sheng WD contributed to data curation and investigation; Zhou W, Sheng WD and Liu YW contributed to visualization and software; Zhu JH, Han YL, Qiu XO, and Qian YY contributed to writing (original draft); Liao Z and Li ZS contributed to study supervision; All the authors contributed to writing (review & editing) and approved the final manuscript. Zhu JH and Liu X, as co-first authors, were integral to the study's execution. Zhu JH initiated the research protocol, handled participant recruitment and data collection, performed initial data organization and statistical analysis, and drafted the manuscript, also providing funding. Liu X conceived the research direction, collaborated on trial design specifics, supervised participant inclusion and procedures, proofread data, co-completed statistical analysis, and revised the final manuscript. Their combined efforts were crucial and indispensable. Qian YY and Liao Z, the corresponding authors, made significant and indispensable contributions. Qian YY finalized the study protocol, defined endpoints, provided technical expertise, interpreted statistical results, created figures and tables, and revised the initial draft. Liao Z, an MCE expert, validated the research protocol's scientific basis, monitored progress, ensured quality control, and approved the final conclusions and manuscript submission. Their collaboration is vital for this and future publications.
Supported by Shanghai Municipal Hospital Emerging Frontier Technology Joint Project, No. SHDC12019105; Shanghai Science and Technology Development Funds, No. 24YF2758200; and National Natural Science Foundation of China, No. 82100699.
Institutional review board statement: This study was approved by the Ethics Committee of Changhai Hospital, No. CHCE2020-117.
Clinical trial registration statement: The study was registered at ClinicalTrials.gov (NCT04479423).
Informed consent statement: All patients signed informed consent forms of this trial.
Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.
CONSORT 2010 statement: The authors have read the CONSORT 2010 Statement, and the manuscript was prepared and revised according to the CONSORT 2010 Statement.
Data sharing statement: If requested, deidentified data collected for this trial, the study protocol, and informed consent form can be made available indefinitely. Please contact Zhuan Liao (
liaozhuan@smmu.edu.cn), who will review all requests. Requests should fulfill the following access criteria: Research can only be conducted in collaboration with and after approval of this trial investigators, and with a signed data access and sharing agreement. The members of this trial investigators must approve all research done with the shared data.
Open Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See:
https://creativecommons.org/Licenses/by-nc/4.0/ Corresponding author: Zhuan Liao, MD, PhD, Chief Physician, Professor, Senior Researcher, Department of Gastroenterology, Changhai Hospital, The Naval Medical University, No. 168 Changhai Road, Shanghai 200433, China.
zhuanleo@126.com
Received: February 14, 2025
Revised: April 14, 2025
Accepted: June 9, 2025
Published online: June 28, 2025
Processing time: 132 Days and 23.7 Hours
