Review
Copyright ©The Author(s) 2021. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastroenterol. Aug 21, 2021; 27(31): 5152-5170
Published online Aug 21, 2021. doi: 10.3748/wjg.v27.i31.5152
Helicobacter pylori eradication: Exploring its impacts on the gastric mucosa
Chun-Yan Weng, Jing-Li Xu, Shao-Peng Sun, Kai-Jie Wang, Bin Lv
Chun-Yan Weng, Shao-Peng Sun, Kai-Jie Wang, Bin Lv, Department of Gastroenterology, The First Clinical Medical College of Zhejiang Chinese Medical University, Hangzhou 310053, Zhejiang Province, China
Jing-Li Xu, Department of Gastrointestinal Surgery, The First Clinical Medical College of Zhejiang Chinese Medical University, Hangzhou 310053, Zhejiang Province, China
Bin Lv, Department of Gastroenterology, The First Affiliated Hospital of Zhejiang Chinese Medical University, Hangzhou 310006, Zhejiang Province, China
Author contributions: All authors contributed to the collection of articles, data analysis, and the writing and editing of the final manuscript.
Supported by National Natural Science Foundation of China, No. 722211A00352.
Conflict-of-interest statement: The authors have no potential conflict of interest related to this manuscript.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Bin Lv, MM, Chief Doctor, Professor, Department of Gastroenterology, The First Affiliated Hospital of Zhejiang Chinese Medical University, No. 54 Youdian Road, Hangzhou 310006, Zhejiang Province, China. lvbin@medmail.com.cn
Received: April 14, 2021
Peer-review started: April 14, 2021
First decision: June 3, 2021
Revised: June 14, 2021
Accepted: July 15, 2021
Article in press: July 15, 2021
Published online: August 21, 2021
Processing time: 126 Days and 5.8 Hours
Abstract

Helicobacter pylori (H. pylori) infects approximately 50% of all humans globally. Persistent H. pylori infection causes multiple gastric and extragastric diseases, indicating the importance of early diagnosis and timely treatment. H. pylori eradication produces dramatic changes in the gastric mucosa, resulting in restored function. Consequently, to better understand the importance of H. pylori eradication and clarify the subsequent recovery of gastric mucosal functions after eradication, we summarize histological, endoscopic, and gastric microbiota changes to assess the therapeutic effects on the gastric mucosa.

Keywords: Helicobacter pylori; Gastric mucosa; Histology; Endoscopic findings; Gastrointestinal microbiota; Eradication therapy

Core Tip: Eradication of Helicobacter pylori (H. pylori) is important. Multiple gastrointestinal diseases and extragastric diseases would emerge if H. pylori infection persists, whereas they would improve after H. pylori eradication. Thus, H. pylori eradication produces dramatic changes in the gastric mucosa. This review highlights the most recent literature and presents a comprehensive evaluation about the impact of H. pylori eradication on the gastric mucosa.