Systematic Reviews
Copyright ©The Author(s) 2021. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastroenterol. Jun 21, 2021; 27(23): 3413-3428
Published online Jun 21, 2021. doi: 10.3748/wjg.v27.i23.3413
Local ablation of pancreatic tumors: State of the art and future perspectives
Vincenza Granata, Roberta Grassi, Roberta Fusco, Andrea Belli, Raffaele Palaia, Gianpaolo Carrafiello, Vittorio Miele, Roberto Grassi, Antonella Petrillo, Francesco Izzo
Vincenza Granata, Roberta Fusco, Antonella Petrillo, Department of Radiology, Istituto Nazionale Tumori –IRCCS- Fondazione G. Pascale, Naples 80131, Italy
Roberta Grassi, Department of Radiology, Università degli Studi della Campania Luigi Vanvitelli, Naples 80127, Italy
Andrea Belli, Raffaele Palaia, Francesco Izzo, Department of Surgery, Istituto Nazionale Tumori –IRCCS- Fondazione G. Pascale, Naples 80131, Italy
Gianpaolo Carrafiello, Department of Surgery, Università degli Studi di Milano, Milano 20122, Italy
Vittorio Miele, Roberto Grassi, Italian Society of Medical and Interventional Radiology SIRM, SIRM Foundation Milan 20122, Italy
Vittorio Miele, Department of Emergency Radiology, San Camillo Hospital, Firenze 50139, Italy
Roberto Grassi, Department of Radiology, Università degli Studi della Campania Luigi Vanvitelli, Naples 80127, Italy
Author contributions: Each author has participated sufficiently in any submission to take public responsibility for its content: Conceptualization; data curation; formal analysis; investigation; methodology; supervision; validation; visualization; roles/writing-original draft; and writing-review and editing.
Conflict-of-interest statement: No conflict of interest.
PRISMA 2009 Checklist statement: The authors have read the PRISMA 2009 Checklist statement, and the manuscript was prepared and revised according to the PRISMA 2009 Checklist statement.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Roberta Fusco, PhD, Technician, Department of Radiology, Istituto Nazionale Tumori –IRCCS- Fondazione G. Pascale, Via Mariano Semmola, Naples 80131, Italy. r.fusco@istitutotumori.na.it
Received: March 7, 2021
Peer-review started: March 7, 2021
First decision: March 27, 2021
Revised: March 28, 2021
Accepted: May 8, 2021
Article in press: May 8, 2021
Published online: June 21, 2021
Processing time: 102 Days and 9.8 Hours
Abstract
BACKGROUND

Currently, the technologies most commonly used to treat locally advanced pancreatic cancer are radiofrequency ablation (RFA), microwave ablation, and irreversible (IRE) or reversible electroporation combined with low doses of chemotherapeutic drugs.

AIM

To report an overview and updates on ablative techniques in pancreatic cancer.

METHODS

Several electronic databases were searched. The search covered the years from January 2000 to January 2021. Moreover, the reference lists of the found papers were analysed for papers not indexed in the electronic databases. All titles and abstracts were analysed.

RESULTS

We found 30 studies (14 studies for RFA, 3 for microwave therapy, 10 for IRE, and 3 for electrochemotherapy), comprising 1047 patients, which were analysed further. Two randomized trials were found for IRE. Percutaneous and laparotomy approaches were performed. In the assessed patients, the median maximal diameter of the lesions was in the range of 2.8 to 4.5 cm. All series included patients unfit for surgical treatment, but Martin et al assessed a subgroup of patients with borderline resectable tumours who underwent resection with margin attenuation with IRE. Most studies administered chemotherapy prior to ablative therapies. However, several studies suggest that the key determinant of improved survival is attributable to ablative treatment alone. Nevertheless, the authors suggested chemotherapy before local therapies for several reasons. This strategy may not only downstage a subgroup of patients to curative-intent surgery but also support to recognize patients with biologically unfavourable tumours who would likely not benefit from ablation treatments. Ablation therapies seem safe based on the 1047 patients assessed in this review. The mortality rate ranged from 1.8% to 2%. However, despite the low mortality, the reported rates of severe post procedural complications ranged from 0%-42%. Most reported complications have been self-limiting and manageable. Median overall survival varied between 6.0 and 33 mo. Regarding the technical success rate, assessed papers reported an estimated rate in the range of 85% to 100%. However, the authors reported early recurrence after treatment. A distinct consideration should be made on whether local treatments induce an immune response in the ablated area. Preclinical and clinical studies have shown that RFA is a promising mechanism for inducing antigen-presenting cell infiltration and enhancing the systemic antitumour T-cell immune response and tumour regression.

CONCLUSION

In the management of patients with pancreatic cancer, the possibility of a multimodal approach should be considered, and conceptually, the combination of RFA with immunotherapy represents a novel angle of attack against this tumour.

Keywords: Pancreatic cancer; Ablation treatment; Radiofrequency ablation; Microwave ablation; Irreversible; Electrochemotherapy

Core Tip: In the current state of knowledge, the most commonly used technologies in locally advanced pancreatic cancer are radiofrequency ablation, microwave ablation, and irreversible or reversible electroporation combined with low doses of chemotherapeutic drugs. Our purpose is to report an updated overview of these techniques, highlighting the advantages and limitations of each technology.