Published online Feb 14, 2018. doi: 10.3748/wjg.v24.i6.744
Peer-review started: December 8, 2017
First decision: December 21, 2017
Revised: January 3, 2018
Accepted: January 16, 2018
Article in press: January 16, 2018
Published online: February 14, 2018
To describe contrast-enhanced ultrasound (CEUS) features and evaluate differential diagnosis value of CEUS and conventional ultrasound for patients with benign and malignant gallbladder lesions.
This study included 105 gallbladder lesions. Before surgical resection and pathological examination, conventional ultrasound and CEUS were performed to examine for lesions. Then, all the lesions were diagnosed as (1) benign, (2) probably benign, (3) probably malignant or (4) malignant using both conventional ultrasound and CEUS. The CEUS features of these gallbladder lesions were analyzed and diagnostic efficiency between conventional ultrasound and CEUS was compared.
There were total 17 cases of gallbladder cancer and 88 cases of benign lesion. Some gallbladder lesions had typical characteristics on CEUS (e.g., gallbladder adenomyomatosis had typical characteristics of small nonenhanced areas on CEUS). The sensitivity, specificity, positive predictive value, negative predictive value and accuracy of CEUS were 94.1%, 95.5%, 80.0%, 98.8% and 95.2%, respectively. These were significantly higher than conventional ultrasound (82.4%, 89.8%, 60.9%, 96.3% and 88.6%, respectively). CEUS had an accuracy of 100% for gallbladder sludge and CEUS helped in differential diagnosis among gallbladder polyps, gallbladder adenoma and gallbladder cancer.
CEUS may provide more useful information and improve the diagnosis efficiency for the diagnosis of gallbladder lesions than conventional ultrasound.
Core tip: With the advent of ultrasound contrast agents, contrast-enhanced ultrasound (CEUS) is playing a more and more important role clinically. However, the value of CEUS in gallbladder lesions has not been widely accepted yet. In this study, we evaluated the differential diagnosis value of CEUS and conventional ultrasound for patients with benign and malignant gallbladder lesions. Our results showed that CEUS may provide more useful information and improve diagnosis efficiency for the diagnosis of gallbladder lesions than conventional ultrasound.