Published online Jul 14, 2018. doi: 10.3748/wjg.v24.i26.2818
Peer-review started: April 6, 2018
First decision: April 19, 2018
Revised: May 19, 2018
Accepted: June 2, 2018
Article in press: June 2, 2018
Published online: July 14, 2018
Gastric cancer (GC) is one of the most prevalent malignant types in the world and an aggressive disease with a poor 5-year survival. This cancer is biologically and genetically heterogeneous with a poorly understood carcinogenesis at the molecular level. Although the incidence is declining, the outcome of patients with GC remains dismal. Thus, the detection at an early stage utilizing useful screening approaches, selection of an appropriate treatment plan, and effective monitoring is pivotal to reduce GC mortalities. Identification of biomarkers in a basis of clinical information and comprehensive genome analysis could improve diagnosis, prognosis, prediction of recurrence and treatment response. This review summarized the current status and approaches in GC biomarker, which could be potentially used for early diagnosis, accurate prediction of therapeutic approaches and discussed the future perspective based on the molecular classification and profiling.
Core tip: Gastric cancer (GC) is one of the most common leading causes of cancer death in the world. Hence, any effort in early diagnosis, choice of appropriate therapeutic strategies and efficient monitoring can have a pivotal role in reducing the disease related mortalities. Our review purpose the current trends in GC biomarker which are classified as pathologic signaling, genetic or epigenetic changes within the tumor tissue as well as non-invasive biomarkers such as blood or gastric juice based markers. These biomarkers could facilitate more individualized treatment approaches.