Basic Study
Copyright ©The Author(s) 2018. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastroenterol. Jan 14, 2018; 24(2): 211-215
Published online Jan 14, 2018. doi: 10.3748/wjg.v24.i2.211
Novel concept of endoscopic device delivery station system for rapid and tight attachment of polyglycolic acid sheet
Hirohito Mori, Hideki Kobara, Noriko Nishiyama, Tsutomu Masaki
Hirohito Mori, Hideki Kobara, Noriko Nishiyama, Tsutomu Masaki, Departments of Gastroenterology and Neurology, Kagawa University, Kagawa 761-0793, Japan
Author contributions: Mori H was responsible for devising the research and writing the manuscript; Kobara H and Nishiyama N participated equally in the work; Masaki T provided a critical revision of the manuscript for intellectual content and was responsible for final approval of the manuscript.
Supported by The Translational Research Program and the Strategic Promotion for Practical Applications of Innovative Medical Technology (TR-SPRINT) from the Japan Agency for Medical Research and Development (AMED).
Institutional review board statement: This Animal experiment was approved by Animal Laboratory Regulations of Kagawa University according to the Regulations and Guidelines of animal experiment of Kagawa University. [See the supplement PDF file of Institutional Review Board Approval Form (Approval No: A34) of Kagawa University].
Institutional animal care and use committee statement: Animal experiments were performed based on Preclinical Animal Laboratory of Kagawa University according to the guidelines of animals by Kagawa University.
Conflict-of-interest statement: All authors declare that they have no conflicts of interest, and no corporate financing was received.
Data sharing statement: Technical procedures and dataset are available from the corresponding author at [].
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See:
Correspondence to: Hirohito Mori, MD, PhD, Associate Professor, Department of Gastroenterology and Neurology, Kagawa University School of Medicine, 1750-1 Ikenobe, Miki, Kita, Kagawa 761-0793, Japan.
Telephone: +81-87-891-2156 Fax: +81-87-891-2158
Received: November 6, 2017
Peer-review started: November 7, 2017
First decision: November 14, 2017
Revised: November 27, 2017
Accepted: December 5, 2017
Article in press: December 5, 2017
Published online: January 14, 2018

To evaluate appropriate and rapid polyglycolic acid sheet (PGAs) covering time using device delivery station system (DDSS).


This pilot basic study was conducted to evaluate the potential of accurate and rapid PGAs delivery using DDSS. Three 11-mo-old female Beagle dogs were used in this study. Two endoscopic submucosal dissections (ESDs) 4cm in diameter were performed in lesser curvature of middle gastric body and greater curvature of antrum (total 6 ESDs performed). DDSS (3 cm length, 12 mm in outer diameter) has 2 chambers which 16 cm2 large 2 PGAs were stored, and DDSS was attached post ESD ulcers, respectively. Beriplast P® (CSL Behring K.K., Tokyo, Japan) (combination of fibrin glue and thrombin) was applied equally to the artificial ulcer, and tight attachment of 2 PGAs with DDSS were completed. The evaluation items were covering times, post ESD bleeding and perforation during ESD.


The covering time of PGAs (defined as the duration from the beginning of endoscope insertion into the mouth to the end of the fibrin glue coating process) was 6.07 (4.86-8.29) min. There was no post-ESD bleeding (1-7 d after ESD), and there was no perforation during ESD.


DDSS was very useful for rapid delivering and tight attachment of PGAs, and has potentials of multi-purpose delivery station system.

Keywords: Post-endoscopic submucosal dissection ulcers, Bleeding, Polyglycolic acid sheet, Rapidly delivery, Tightly attachment

Core tip: Although mechanical closures of larger artificial ulcer floor are effective to prevent post-endoscopic submucosal dissection (ESD) bleeding, mechanical closures might create a mucosal bridge which reduces the efficacy of prevention of post-ESD bleeding. Although covering with polyglycolic acid sheet (PGAs) is a more ideal treatment, it is difficult to deliver thin PGAs by pan-endoscope. Therefore, novel concept to deliver various devices and materials were developed.