Published online Apr 21, 2018. doi: 10.3748/wjg.v24.i15.1616
Peer-review started: March 14, 2018
First decision: March 30, 2018
Revised: April 1, 2018
Accepted: April 16, 2018
Article in press: April 16, 2018
Published online: April 21, 2018
To date, various signal transducers, cytokines, growth factors, and hormones have been reported to play an important role in homeostasis of various organs. Various cells and organs are involved in the hepatic regeneration process, which proceeds as a result of the coordination of many factors. While these factors are well known to be involved in the liver regeneration after the liver injury, however, as the details of such mechanisms have not been sufficiently elucidated, the practical applicability of hepatic regeneration based on the action of these and cytokines growth factors is still unclear. In terms of the involvement of the autonomic nervous system in hepatic regeneration, cell proliferation resulting from direct signal transduction to the liver has also been reported and recent studies focusing on the inter-organ communication via neural network opened a novel aspect of this field for therapeutic applicability. Therefore, the appropriate understanding of the relationship between autonomic neural network and liver regeneration through various organs including brain, afferent nerve, efferent nerve, etc. is essential. This mini-review explains the principle of neural system involved in the inter-organ communication and its contribution on the liver regeneration upon the liver injury reviewing recent progress in this field.
Core tip: The review of the relationship between autonomic neural network and liver regeneration shows that an inter-organ communication is functioning in a coordinated manner through the autonomic nervous system as a biological mechanism for hepatic regeneration and functional maintenance when the liver is damaged. Therefore, this mini-review presents how autonomic nerve fibers affect hepatic regeneration including the results of our most recent research.