Tamura H, Saiki H, Amano T, Yamamoto M, Hayashi S, Ando H, Doi R, Nishida T, Yamamoto K, Adachi S. Esophageal carcinoma originating in the surface epithelium with immunohistochemically proven esophageal gland duct differentiation: A case report. World J Gastroenterol 2017; 23(21): 3928-3933 [PMID: 28638233 DOI: 10.3748/wjg.v23.i21.3928]
Corresponding Author of This Article
Hiromi Tamura, MD, Clinical Fellow, Department of Pathology, City Hospital of Toyonaka, Shibahara-cho 4-14-1, Toyonaka, Osaka 560-8565, Japan. watanabehiromi1107@hotmail.com
Research Domain of This Article
Pathology
Article-Type of This Article
Case Report
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Hiromi Tamura, Hiroka Ando, Reiko Doi, Shiro Adachi, Department of Pathology, City Hospital of Toyonaka, Osaka 560-8565, Japan
Takahiro Amano, Masashi Yamamoto, Shiro Hayashi, Tsutomu Nishida, Department of Gastroenterology, City Hospital of Toyonaka, Osaka 560-8565, Japan
Hirotsugu Saiki, Katsumi Yamamoto, Department of Gastroenterology, JCHO Osaka Hospital, Osaka 553-0003, Japan
Author contributions: Tamura H wrote the manuscript; Ando H and Doi R contributed equally to this work by discussing the immunohistochemical data and histological diagnosis; Saiki H, Amano T, Yamamoto M, Hayashi S, Nishida T and Yamamoto K assessed the patients; Adachi S critically reviewed the manuscript.
Informed consent statement: Informed consent was obtained from the patient.
Conflict-of-interest statement: We have no conflict of interest in reporting the present case.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Correspondence to: Hiromi Tamura, MD, Clinical Fellow, Department of Pathology, City Hospital of Toyonaka, Shibahara-cho 4-14-1, Toyonaka, Osaka 560-8565, Japan. watanabehiromi1107@hotmail.com
Telephone: +81-6-68430101 Fax: +81-6-68583531
Received: January 10, 2017 Peer-review started: January 12, 2017 First decision: March 3, 2017 Revised: March 17, 2017 Accepted: April 12, 2017 Article in press: April 12, 2017 Published online: June 7, 2017
Abstract
A case of esophageal carcinoma exclusively composed of adenocarcinoma simulating an esophageal gland duct in a 61-year-old man is presented. The tumor arose as a slightly elevated lesion in the middle intrathoracic esophagus. It was almost completely overlaid with non-neoplastic stratified squamous epithelial cells. Beneath the overlying surface epithelium, an adenocarcinoma that was bilayered in structure diffusely invaded both the mucosal and submucosal layers. Although the tumor consisted exclusively of adenocarcinomatous cells, a keratinizing squamous cell carcinoma component was focally observed. The invasive carcinoma was focally continuous with the small area of the surface squamous epithelial layer, which was confirmed to be neoplastic by immunohistochemistry. Morphological and immunohistochemical examinations suggested that the adenocarcinomatous component arose from the esophageal surface epithelium and clearly differentiated into an esophageal gland duct. It is important to consider the possibility of this type of adenocarcinoma when diagnosing a ductal or glandular lesion of the esophagus in small biopsy specimens.
Core tip: We present a case of esophageal carcinoma exclusively composed of adenocarcinoma simulating an esophageal gland duct. Morphologic and immunohistochemical examinations proved that adenocarcinomatous component here arose from the esophageal surface epithelium and showed a clear differentiation toward an esophageal gland duct. It is important to consider the possibility of this type of adenocarcinoma when diagnosing a ductal or glandular lesion of the esophagus in small biopsy specimens.
