Published online Jun 7, 2017. doi: 10.3748/wjg.v23.i21.3883
Peer-review started: February 8, 2017
First decision: March 3, 2017
Revised: March 20, 2017
Accepted: May 4, 2017
Article in press: May 4, 2017
Published online: June 7, 2017
To investigated the prognostic value of the neutrophil-lymphocyte ratio (NLR) in patients with acute pancreatitis and determined an optimal cut-off value for the prediction of adverse outcomes in these patients.
We retrospectively analyzed 490 patients with acute pancreatitis diagnosed between March 2007 and December 2012. NLRs were calculated at admission and 24, 48, and 72 h after admission. Patients were grouped according to acute pancreatitis severity and organ failure occurrence, and a comparative analysis was performed to compare the NLR between groups.
Among the 490 patients, 70 had severe acute pancreatitis with 31 experiencing organ failure. The severe acute pancreatitis group had a significantly higher NLR than the mild acute pancreatitis group on all 4 d (median, 6.14, 6.71, 5.70, and 4.00 vs 4.74, 4.47, 3.20, and 3.30, respectively, P < 0.05). The organ failure group had a significantly higher NLR than the group without organ failure on all 4 d (median, 7.09, 6.72, 6.27, and 6.24 vs 4.85, 4.49, 3.35, and 2.34, respectively, P < 0.05). The optimal cut-off value for baseline NLR was 4.76 in predicting severity and 4.88 in predicting organ failure in acute pancreatitis.
Elevated baseline NLR correlates with severe acute pancreatitis and organ failure.
Core tip: This is a retrospective study to demonstrate the usefulness of the neutrophil-lymphocyte ratio in predicting the manifestation of severe acute pancreatitis and organ failure in the early stages in patients with acute pancreatitis. The neutrophil-lymphocyte ratio is cost-effective and easy to use, utilizing tests already routinely performed. This study found the neutrophil-lymphocyte ratio to be a reliable predictor of adverse outcomes in patients with acute pancreatitis and established the optimal cut-off value of the neutrophil-lymphocyte ratio for predicting these outcomes.